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Peptide Profile

NAD+

NAD · NAD+ 500 · NAD+ IV Therapy · Nicotinamide Adenine Dinucleotide

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional…

Longevity & CellularMixed
Used forlongevitycognitiverecovery
Half-life
~1–2 hours (IV); variable (oral)
Routes
intravenous, subcutaneous, oral
Find providers View evidence

Educational research information — not medical advice. Review primary sources and consult a qualified professional before any decision.

Educational research tools — not medical advice.

Overview

What NAD+ is

About NAD+

NAD+ is a coenzyme central to cellular energy metabolism, serving as an electron carrier in glycolysis, the citric acid cycle, and oxidative phosphorylation. It is also a required substrate for sirtuins (SIRT1–7) and PARP enzymes, which regulate DNA repair, gene expression, and mitochondrial biogenesis. NAD+ levels decline measurably with age; IV or subcutaneous delivery aims to restore intracellular pools more directly than oral precursors such as NMN or NR.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional medicine and longevity providers via intravenous infusion or subcutaneous injection. Research interest centres on its role in mitochondrial health, cellular resilience, and neurological function as NAD+ levels decline with age. NAD+ IV therapy: intravenous NAD+ infusion is the administration route that has attracted the most clinical interest, particularly in longevity and functional medicine contexts. IV NAD+ therapy delivers the compound directly into the bloodstream, bypassing digestive absorption — a route considered relevant given that oral NAD+ precursors (NMN, NR) have variable bioavailability. NAD+ IV therapy cost typically ranges from $200–$1,000 per session depending on the clinic, infusion volume, and geographic market; treatment frequency in clinical settings commonly ranges from weekly to monthly maintenance infusions following an initial loading protocol. NAD+ IV therapy clinics operate across major US markets including Houston, Los Angeles, New York, and Las Vegas. For those researching where to find NAD+ IV therapy providers, PeptideBase maintains a directory of clinics and telehealth platforms offering NAD+ protocols.

NAD+ Benefits & Research Areas

NAD+/NADH ratio restoration supporting cellular energy productionsirtuin pathway activation (SIRT1–SIRT7) linked to aging researchDNA repair cofactor — PARP enzyme activity dependent on NAD+IV therapy context: $200–$1,000/session; oral NMN/NR as alternative routes

Research Signals

Commonly researched in the context of

Hormonal ChangesPoor SleepHigh Stress

Population research notes

30s40s50+

These signals reflect research interest areas, not treatment indications.

Pharmacokinetics

NAD+ half-life calculator

Compound & timing

Half-lifefrom PeptideBase data
Source: "~1–2 hours (IV); variable (oral)" · NAD+ (PeptideBase)
to show amount remaining
2 h
0%25%50%75%100%02.14.26.28.310time since dose (h)
Plasma decay curve for NAD+: 25% to 50% remaining at 2 h after the dose.
range (~1–2 hours (IV); variable (oral))slower half-life
25%–50%remaining in plasmaat 2 h after the dose
Half-life
1 – 2 h
~97% cleared after
10 h

Model: single-dose, first-order (single-compartment) estimate. Real clearance is multi-compartment and varies by individual and route.

The Research

What the evidence says about NAD+

Research Evidence

based on 4 studies · 2 RCTs · most recent 2026

Regulatory Status

Availability Status
Mixed
FDA Status
Effective Date
September 5, 2019
Source
View FDA source →

Available OTC as supplement. IV/injection forms offered by clinics without FDA evaluation as a drug.

Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

Research Sources

4 sources cited · 2 strong · 2 weak

2 RCTs · 2 Reviews

  • Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

    Science · 2021

    Research found that 10 weeks of NMN supplementation significantly increased skeletal muscle insulin sensitivity and insulin signaling in postmenopausal women with prediabetes who were overweight or obese, compared with placebo.

    RCTn=25StrongPMID 33888596

  • Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

    Nature Communications · 2018

    In a randomized crossover clinical trial, chronic nicotinamide riboside supplementation was well tolerated and effectively elevated NAD+ metabolism in healthy middle-aged and older adults, with initial findings suggesting potential benefits for reducing blood pressure and arterial stiffness.

    RCTStrongPMID 29599478

  • Mitochondrial quality control in human ageing and longevity.

    Nat Metab · 2026

    ReviewTheoreticalPMID 42374094
Show 1 more source ↓

  • Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

    Cell Metabolism · 2018

    This review summarizes in vivo evidence that NAD+ levels decline steadily with age and that restoring NAD+ in aged or diseased animal models extends healthspan and improves metabolic function, supporting NAD+ precursor molecules as promising research targets for age-related conditions.

    ReviewTheoreticalPMID 29514064

NAD+ Side Effects & Safety Considerations

Research-use compound with limited human data. Evidence strength varies — see the Evidence section.

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.

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VS

NAD+

Third-party testing data

Limited testing data (1 verified result)

We only show a verified-testing signal once at least 3 independent lab results are on file. Below that, we show what we have without implying a confidence signal.

PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Certificates of Analysis

24 COAs on record for NAD+

PeptideBase reports these lab-published figures and does not itself test, endorse, or certify any product. Confirmed by lab results were matched against the issuing laboratory's own records — either the lab served the document, or its own hosted copy matches ours byte for byte. For every other result the badge states what is known about the lab: that it can be checked and no result is recorded yet, that it can't be checked, or that we have not reviewed it.

PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Community Experience

What people report about NAD+

n=23early data

Self-reported, anecdotal experiences aggregated from public Reddit discussions — community sentiment, not clinical evidence or medical advice.

Attribution note: many of these reports describe stacking NAD+ with other compounds, so outcomes may not be attributable to it alone.

Outcome distribution

70%improved
Improved
16 · 70%
Mixed
2 · 9%
No clear effect
3 · 13%
Worse
2 · 9%

Outcomes by goal · improved % · reports

Energy & vitality79% improved · 14 reports

Side effects people mention

Counts are mentions across reports, not incidence rates.

Elevated heart rate2
Injection site reaction2
Dizziness1
Joint pain1
Nausea1

Most reported

What they wish they'd known

  • Unexpected physical side effects emerged that users did not anticipate before starting2×thread 1thread 2
  • Effects often took time to appear and were not immediately obvious after starting2×thread 1thread 2
  • Cheaper or simpler alternatives were later found to produce comparable experiences2×thread 1thread 2
  • When stacking multiple compounds it becomes difficult to attribute benefits to NAD+ alone4×thread 1thread 2thread 3

Based on 23 community reports · Updated

Frequently Asked Questions — NAD+

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional medicine and longevity providers via intravenous infusion or subcutaneous injection.

NAD+/NADH ratio restoration supporting cellular energy production, sirtuin pathway activation (SIRT1–SIRT7) linked to aging research, DNA repair cofactor — PARP enzyme activity dependent on NAD+, IV therapy context: $200–$1,000/session; oral NMN/NR as alternative routes.

Research on NAD+ primarily documents effects related to NAD+/NADH ratio restoration supporting cellular energy production and sirtuin pathway activation (SIRT1–SIRT7) linked to aging research and DNA repair cofactor — PARP enzyme activity dependent on NAD+ and IV therapy context: $200–$1,000/session; oral NMN/NR as alternative routes. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.

For NAD+, its FDA status is Evaluated Not Recommended, and it is of mixed availability depending on formulation. Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

396 providers in the directory currently offer NAD+.

Across 19 research vendors tracked on PeptideBase, NAD+ has a median price of about $0.14 per mg, typically ranging $0.10–$0.18 per mg. This reflects research-use vendor pricing, not clinical or prescription costs.

Research found that 10 weeks of NMN supplementation significantly increased skeletal muscle insulin sensitivity and insulin signaling in postmenopausal women with prediabetes who were overweight or obese, compared with placebo.

Access

How to get NAD+

Market Pricing

19 vendors
$0.10/mgBudget
$0.14/mgMedian
$0.18/mgPremium
$0.10
$0.14
$0.18

Price per mg varies by quantity, vendor type, and formulation. Research use only.

Data verified August 2026 · NAD+ price intelligence

Compare 19 vendors →
Compare all 19 vendors →

Where to buy NAD+

396 providers
●318 Clinics●16 Telehealth●25 Pharmacies●37 Online Vendors446 in stock5 on request
10/10

Compounding Pharmacies (503A)

1 provider
View all 396 providers →

Questions to ask your provider

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Last updated

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Tools & Guides

Reconstitution Calculator

Convert vial size + BAC water volume into draw volume.

How to Reconstitute Peptides

Step-by-step guide: BAC water, vial prep, and storage after mixing.

Peptide Dosage Guide

Key factors that determine dosing in clinical practice.

Peptide Storage Guide

How to store lyophilized and reconstituted peptides.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). NAD+ — Per-mg Price Benchmark. Retrieved September 11, 2026, from https://peptidebase.io/peptides/nad-plus
https://peptidebase.io/peptides/nad-plusMethodologyLicenseDownload JSONDownload CSV

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