Peptide Profile
NAD+
NAD · Nicotinamide Adenine Dinucleotide · NAD+ IV Therapy
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional…
- Half-life
- ~1–2 hours (IV); variable (oral)
- Routes
- intravenous, subcutaneous, oral
Educational research information — not medical advice. Review primary sources and consult a qualified professional before any decision.
Educational research tools — not medical advice.
What NAD+ is
About NAD+
NAD+ is a coenzyme central to cellular energy metabolism, serving as an electron carrier in glycolysis, the citric acid cycle, and oxidative phosphorylation. It is also a required substrate for sirtuins (SIRT1–7) and PARP enzymes, which regulate DNA repair, gene expression, and mitochondrial biogenesis. NAD+ levels decline measurably with age; IV or subcutaneous delivery aims to restore intracellular pools more directly than oral precursors such as NMN or NR.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional medicine and longevity providers via intravenous infusion or subcutaneous injection. Research interest centres on its role in mitochondrial health, cellular resilience, and neurological function as NAD+ levels decline with age. NAD+ IV therapy: intravenous NAD+ infusion is the administration route that has attracted the most clinical interest, particularly in longevity and functional medicine contexts. IV NAD+ therapy delivers the compound directly into the bloodstream, bypassing digestive absorption — a route considered relevant given that oral NAD+ precursors (NMN, NR) have variable bioavailability. NAD+ IV therapy cost typically ranges from $200–$1,000 per session depending on the clinic, infusion volume, and geographic market; treatment frequency in clinical settings commonly ranges from weekly to monthly maintenance infusions following an initial loading protocol. NAD+ IV therapy clinics operate across major US markets including Houston, Los Angeles, New York, and Las Vegas. For those researching where to find NAD+ IV therapy providers, PeptideBase maintains a directory of verified clinics and telehealth platforms offering NAD+ protocols.
NAD+ Benefits & Research Areas
Research Signals
Commonly researched in the context of
Population research notes
These signals reflect research interest areas, not treatment indications.
NAD+ half-life calculator
Compound & timing
Model: single-dose, first-order (single-compartment) estimate. Real clearance is multi-compartment and varies by individual and route.
What the evidence says about NAD+
Research Evidence
based on 8 studies · 2 RCTs · most recent 2026
Regulatory Status
- Availability Status
- Mixed
- FDA Status
- Effective Date
- September 5, 2019
- Source
- View FDA source →
Available OTC as supplement. IV/injection forms offered by clinics without FDA evaluation as a drug.
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Research Sources
8 sources cited · 3 strong · 5 moderate
2 RCTs · 3 Cohorts · 3 Reviews
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Science · 2021
Research found that 10 weeks of NMN supplementation significantly increased skeletal muscle insulin sensitivity and insulin signaling in postmenopausal women with prediabetes who were overweight or obese, compared with placebo.
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Nature Communications · 2018
In a randomized crossover clinical trial, chronic nicotinamide riboside supplementation was well tolerated and effectively elevated NAD+ metabolism in healthy middle-aged and older adults, with initial findings suggesting potential benefits for reducing blood pressure and arterial stiffness.
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Cell Metabolism · 2018
This review summarizes in vivo evidence that NAD+ levels decline steadily with age and that restoring NAD+ in aged or diseased animal models extends healthspan and improves metabolic function, supporting NAD+ precursor molecules as promising research targets for age-related conditions.
Show 5 more sources ↓
Extracellular Lactate Reprograms Mitochondrial Metabolism and NAD(+)/NADH Redox Balance in Blood-Brain Barrier Endothelial Cells via an LDHB-MPC-NAD(+) Axis.
Free Radic Biol Med · 2026
# Summary Research found that extracellular lactate reprograms blood-brain barrier endothelial cells to shift from glucose-dependent glycolysis toward mitochondrial oxidative metabolism through an LDHB-MPC-NAD+ signaling axis. This study demonstrated that lactate oxidation activates NAD+ salvage pathways to maintain redox balance while supporting enhanced mitochondrial function and cell proliferation, establishing a novel metabolic feedback mechanism in cerebrovascular endothelial cells.
Mitochondrial quality control in human ageing and longevity.
Nat Metab · 2026
Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.
Front Aging · 2026
Effects of Kiperin Elixea, a multicomponent antioxidant supplement, on redox homeostasis and longevity-associated gene expression in human epithelial cell models.
Front Aging · 2026
Mitochondrial quality control in human ageing and longevity.
Nat Metab · 2026
NAD+ Side Effects & Safety Considerations
Research-use compound with limited human data. Evidence strength varies — see the Evidence section.
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
Third-party testing data
Limited testing data (1 verified result)
We only show a verified-testing signal once at least 3 independent lab results are on file. Below that, we show what we have without implying a confidence signal.
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.
Certificates of Analysis
- VerifiedPeptide Partners
NAD+ · May 28, 2026 · View source COA
99.5%
Purity
- Vendor-publishedPurity Peptides
NAD+ · Lot 260501NA5005 · May 15, 2026
99.8%
Purity
- Vendor-publishedNextGen Peptides
NAD - 500mg · Lot ND500-4 · May 10, 2026
99.8%
Purity
- Vendor-publishedNextGen Peptides
NAD - 500mg · Lot NAD-08 · Apr 21, 2026
99.5%
Purity
- Vendor-publishedPivot Labs Global
NAD+ 1000 mg · Lot FP25-0090 · Jul 8, 2025 · View source COA
99.2%
Purity
PeptideBase reports these lab-published figures and does not itself test, endorse, or certify any product. Verified results come from an independent third-party lab database lookup. Vendor-published results are reported by the vendor itself and have not been independently verified by PeptideBase or a third-party lab.
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.
What people report about NAD+
Self-reported, anecdotal experiences aggregated from public Reddit discussions — community sentiment, not clinical evidence or medical advice.
Attribution note: many of these reports describe stacking NAD+ with other compounds, so outcomes may not be attributable to it alone.
Outcome distribution
- Improved
- 16 · 70%
- Mixed
- 2 · 9%
- No clear effect
- 3 · 13%
- Worse
- 2 · 9%
Outcomes by goal · improved % · reports
Side effects people mention
Counts are mentions across reports, not incidence rates.
Most reported
- Several people credited NAD+ as a meaningful part of their long COVID symptom recovery5×thread 1thread 2thread 3
- Some users found NAD+ helpful in reducing alcohol cravings and supporting sobriety2×thread 1thread 2
- A subset of users questioned whether NAD+ produced real effects beyond placebo3×thread 1thread 2thread 3
- NAD+ was frequently used alongside other compounds making its isolated impact unclear6×thread 1thread 2thread 3
What they wish they'd known
- Unexpected physical side effects emerged that users did not anticipate before starting2×thread 1thread 2
- Effects often took time to appear and were not immediately obvious after starting2×thread 1thread 2
- Cheaper or simpler alternatives were later found to produce comparable experiences2×thread 1thread 2
- When stacking multiple compounds it becomes difficult to attribute benefits to NAD+ alone4×thread 1thread 2thread 3
Based on 23 community reports · Updated
Frequently Asked Questions — NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional medicine and longevity providers via intravenous infusion or subcutaneous injection.
NAD+/NADH ratio restoration supporting cellular energy production, sirtuin pathway activation (SIRT1–SIRT7) linked to aging research, DNA repair cofactor — PARP enzyme activity dependent on NAD+, IV therapy context: $200–$1,000/session; oral NMN/NR as alternative routes.
Research on NAD+ primarily documents effects related to NAD+/NADH ratio restoration supporting cellular energy production and sirtuin pathway activation (SIRT1–SIRT7) linked to aging research and DNA repair cofactor — PARP enzyme activity dependent on NAD+ and IV therapy context: $200–$1,000/session; oral NMN/NR as alternative routes. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.
For NAD+, its FDA status is Evaluated Not Recommended, and it is of mixed availability depending on formulation. Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
393 providers in the directory currently offer NAD+.
Across 49 research vendors tracked on PeptideBase, NAD+ has a median price of about $0.12 per mg, typically ranging $0.10–$0.18 per mg. This reflects research-use vendor pricing, not clinical or prescription costs.
Research found that 10 weeks of NMN supplementation significantly increased skeletal muscle insulin sensitivity and insulin signaling in postmenopausal women with prediabetes who were overweight or obese, compared with placebo.
How to get NAD+
Market Pricing
49 vendorsPrice per mg varies by quantity, vendor type, and formulation. Research use only.
Data verified July 2026 · NAD+ price intelligence
Where to buy NAD+
393 providersClinics
9 providersAdvanced Age Management
Sharon Center, United StatesView →Advantage Wellness Center
Mount Vernon, United StatesView →Aesura Health
Hackensack, United StatesView →Affinity Whole Health
Carmel, United StatesView →AMAVA Regenerative Medicine Peoria-Glendale AZ
Peoria, United StatesView →Atlanta Men's Clinic
Suwanee, CanadaView →Atlas Men's Health
New York, United StatesView →Avena Natural Health
Solana Beach, United StatesView →Avendano Health Medical Wellness & Lab
Boca Raton, United StatesView →
Compounding Pharmacies (503A)
1 providerQuestions to ask your provider
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Cite this page
Data last updated July 20, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). NAD+ — Per-mg Price Benchmark. Retrieved July 22, 2026, from https://peptidebase.io/peptides/nad-plus