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LongevityLow Risk

NAD+

Also known as: NAD, Nicotinamide Adenine Dinucleotide, NAD+ IV Therapy

Half-life:
~1–2 hours (IV); variable (oral)

Administration Routes

intravenoussubcutaneousoral
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

NAD+ is a coenzyme central to cellular energy metabolism, serving as an electron carrier in glycolysis, the citric acid cycle, and oxidative phosphorylation. It is also a required substrate for sirtuins (SIRT1–7) and PARP enzymes, which regulate DNA repair, gene expression, and mitochondrial biogenesis. NAD+ levels decline measurably with age; IV or subcutaneous delivery aims to restore intracellular pools more directly than oral precursors such as NMN or NR.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, central to energy production, DNA repair, and sirtuin activation. While not a peptide in the traditional sense, it is widely administered by functional medicine and longevity providers via intravenous infusion or subcutaneous injection. Research interest centres on its role in mitochondrial health, cellular resilience, and neurological function as NAD+ levels decline with age.

Primary Research Areas

  • longevity
  • cognitive
  • recovery

Risk Profile

Low Risk

Generally considered lower risk in research contexts. Consult a healthcare professional before use.

Providers Offering NAD+