FGL vs N-Acetyl Semax

Mimics NCAM-mediated signaling via FGFR (fibroblast growth factor receptor) activation. Stimulates downstream Erk1/2 and PLCγ pathways. Promotes long-term potentiation (LTP) and synaptogenesis.

A peptide derived from the fibronectin type III (FGL) module of neural cell adhesion molecule (NCAM). Promotes synaptic plasticity, memory formation, and neuroprotection in preclinical models by mimicking NCAM-mediated signaling.

Same ACTH(4-7) core as Semax, but structural modifications resist peptidase degradation. Enhances BDNF expression, supports dopaminergic and serotonergic neurotransmission, and modulates NMDA receptor activity.

An acetylated and amidated derivative of Semax with enhanced enzymatic stability and prolonged activity. N-terminal acetylation and C-terminal amidation protect the peptide from degradation, extending its nootropic and neuroprotective effects versus base Semax.