Davunetide vs FGL

Stabilizes microtubules by interacting with tubulin and microtubule-associated proteins. Activates SIRT1, reduces amyloid-β toxicity, and enhances synaptic plasticity. Protects against tau hyperphosphorylation.

An 8-amino acid neuroprotective peptide derived from Activity-Dependent Neuroprotective Protein (ADNP). Among the most potent neuroprotective agents identified in preclinical models. Studied for Alzheimer's disease, schizophrenia, and traumatic brain injury.

Mimics NCAM-mediated signaling via FGFR (fibroblast growth factor receptor) activation. Stimulates downstream Erk1/2 and PLCγ pathways. Promotes long-term potentiation (LTP) and synaptogenesis.

A peptide derived from the fibronectin type III (FGL) module of neural cell adhesion molecule (NCAM). Promotes synaptic plasticity, memory formation, and neuroprotection in preclinical models by mimicking NCAM-mediated signaling.