Peptide Profile
FGL
FGL peptide · NCAM FGL · neural cell adhesion molecule-derived peptide
FGL (EVYVVAENQQGKSKA) is a synthetic 15-amino-acid peptide derived from the fibronectin type III homology domain 2 of the neural cell adhesion molecule (NCAM), designed as a pharmacomimetic agonist of NCAM to activate…
- Routes
- subcutaneous
Educational research information — not medical advice. Review primary sources and consult a qualified professional before any decision.
Educational research tools — not medical advice.
What FGL is
About FGL
Mimics NCAM-mediated signaling via FGFR (fibroblast growth factor receptor) activation. Stimulates downstream Erk1/2 and PLCγ pathways. Promotes long-term potentiation (LTP) and synaptogenesis.
FGL (EVYVVAENQQGKSKA) is a synthetic 15-amino-acid peptide derived from the fibronectin type III homology domain 2 of the neural cell adhesion molecule (NCAM), designed as a pharmacomimetic agonist of NCAM to activate FGFR-mediated neurotrophic signaling and mimic the synaptogenic and neuroprotective effects of NCAM receptor engagement in the central nervous system. FGL activates downstream FGFR signaling to promote synaptic plasticity, neuronal survival, and spatial learning in preclinical models; rodent studies have demonstrated cognitive-enhancing and anxiolytic effects in aged animals and in models of neurodegeneration, establishing a preclinical rationale for further investigation. No published human clinical trials, pharmacokinetic studies, or safety evaluations of FGL have been indexed in PubMed; the entirety of the evidence base consists of animal and in vitro studies, and no regulatory body has approved or evaluated FGL for any human indication. FGL has no FDA approval or regulatory approval in any jurisdiction; it is a research compound with a defined neurotrophic mechanism and an exclusively preclinical evidence base, and no clinical data exists to inform its pharmacokinetics, safety, or therapeutic utility in humans.
FGL Benefits & Research Areas
What the evidence says about FGL
Regulatory Status
- Availability Status
- Research Only
- FDA Status
- Not Evaluated
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
FGL Side Effects & Safety Considerations
Research-use compound with limited human data. Evidence strength varies — see the Evidence section.
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
Frequently Asked Questions — FGL
FGL (EVYVVAENQQGKSKA) is a synthetic 15-amino-acid peptide derived from the fibronectin type III homology domain 2 of the neural cell adhesion molecule (NCAM), designed as a pharmacomimetic agonist of NCAM to activate FGFR-mediated neurotrophic signaling and mimic the synaptogenic and neuroprotective effects of NCAM receptor engagement in the central nervous system. FGL activates downstream FGFR signaling to promote synaptic plasticity, neuronal survival, and spatial learning in preclinical models; rodent studies have demonstrated cognitive-enhancing and anxiolytic effects in aged animals and in models of neurodegeneration, establishing a preclinical rationale for further investigation.
synaptic plasticity, memory enhancement, neuroprotection, LTP promotion.
Research on FGL primarily documents effects related to synaptic plasticity and memory enhancement and neuroprotection and LTP promotion. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.
For FGL, its FDA status is not evaluated by the FDA, and it is designated for research use only. Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
2 providers in the directory currently offer FGL.
How to get FGL
Where to buy FGL
2 providersQuestions to ask your provider
Stay updated on verified FGL providers
New verified providers added weekly — delivered to your inbox.
Last updated
Keep exploring
Tools & Guides
Reconstitution Calculator
Convert vial size + BAC water volume into draw volume.
How to Reconstitute Peptides
Step-by-step guide: BAC water, vial prep, and storage after mixing.
Peptide Dosage Guide
Key factors that determine dosing in clinical practice.
Peptide Storage Guide
How to store lyophilized and reconstituted peptides.