GHK-Cu vs Leuphasyl

GHK-Cu promotes the synthesis of collagen, elastin, glycosaminoglycans, and decorin, contributing to tissue remodelling and wound contraction. It modulates the activity of matrix metalloproteinases (MMPs) — stimulating wound-healing MMPs while suppressing those that degrade healthy tissue. Genomic analysis has identified GHK-Cu as a modulator of over 4,000 genes, including those governing antioxidant defences and anti-inflammatory pathways.

GHK-Cu (copper peptide tripeptide-1) is a naturally occurring plasma copper complex with broad tissue-remodelling activity. It is one of the most extensively researched peptides for skin health, wound healing, and collagen synthesis. Research has explored its effects across dermatological, cosmetic, and systemic contexts, including roles in joint tissue maintenance and anti-inflammatory signalling.

Tetrapeptide that mimics enkephalin to modulate facial muscle contraction; competes with enkephalin for opioid receptor sites in neuromuscular junctions; reduces repetitive muscle micro-contractions

A neuromodulating peptide that reduces expression lines via the enkephalin pathway, distinct from SNARE-inhibiting peptides (Argireline, SNAP-8). Complements those actives through a different mechanism.