GHK-Cu vs Matrixyl

GHK-Cu promotes the synthesis of collagen, elastin, glycosaminoglycans, and decorin, contributing to tissue remodelling and wound contraction. It modulates the activity of matrix metalloproteinases (MMPs) — stimulating wound-healing MMPs while suppressing those that degrade healthy tissue. Genomic analysis has identified GHK-Cu as a modulator of over 4,000 genes, including those governing antioxidant defences and anti-inflammatory pathways.

GHK-Cu (copper peptide tripeptide-1) is a naturally occurring plasma copper complex with broad tissue-remodelling activity. It is one of the most extensively researched peptides for skin health, wound healing, and collagen synthesis. Research has explored its effects across dermatological, cosmetic, and systemic contexts, including roles in joint tissue maintenance and anti-inflammatory signalling.

Palmitoylated pentapeptide fragment of collagen I; binds TGF-β receptors on fibroblasts; upregulates collagen I, III, and fibronectin; procollagen production via MAPK pathway

The original and most clinically validated cosmeceutical peptide. A fatty acid-conjugated collagen fragment that directly stimulates fibroblasts to produce new collagen. Validated in multiple clinical trials.