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Skin & JointLow Risk

Matrixyl

Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS, Palmitoyl Lysyl-Threonyl-Threonyl-Lysyl-Serine

Half-life:
N/A (topical)

Administration Routes

topical
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

Palmitoylated pentapeptide fragment of collagen I; binds TGF-β receptors on fibroblasts; upregulates collagen I, III, and fibronectin; procollagen production via MAPK pathway

The original and most clinically validated cosmeceutical peptide. A fatty acid-conjugated collagen fragment that directly stimulates fibroblasts to produce new collagen. Validated in multiple clinical trials.

Primary Research Areas

  • collagen I and III synthesis
  • fibronectin increase
  • wrinkle reduction
  • skin firmness

Risk Profile

Low Risk

Generally considered lower risk in research contexts. Consult a healthcare professional before use.

Regulatory Status

Research OnlyNot Evaluated by FDA

Cosmetic peptide (palmitoyl pentapeptide-4 / Pal-KTTKS) by Sederma. Collagen-stimulating anti-aging cosmetic ingredient. Not regulated as a drug by FDA. No NDA or IND. Cosmetic only.

Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

Where to Find Matrixyl