Dalargin vs GLP-2

Binds delta and mu opioid receptors with peripheral preference due to limited CNS penetration. Reduces gastric acid secretion, promotes mucosal blood flow, and inhibits ulcer formation via prostaglandin-mediated pathways.

A synthetic hexapeptide opioid analog with a leucine-enkephalin core extended by a C-terminal arginine. Developed in the Soviet Union for gastroprotective and analgesic applications. Studied for GI mucosal protection and pain modulation with peripheral preference.

Binds GLP-2 receptor on intestinal enteroendocrine cells. Promotes enterocyte proliferation and reduces apoptosis, increasing villus height and crypt depth. Strengthens tight junctions and reduces intestinal permeability.

A 33-amino acid intestinal peptide co-secreted with GLP-1 from gut L-cells after eating. A potent intestinal trophic factor promoting gut lining integrity, villus growth, and reduced intestinal permeability. Studied for IBD, leaky gut, and gut repair.