CGRP vs Dalargin

Binds CLR/RAMP1 receptor complex. Causes vasodilation via cAMP/PKA/nitric oxide pathway. Modulates nociceptive signaling in the trigeminal system. Promotes bone healing and has anti-inflammatory effects in peripheral tissues.

A 37-amino acid neuropeptide released from sensory nerve fibers and one of the most potent endogenous vasodilators. Central to migraine pathophysiology and studied for pain modulation, wound healing, and bone repair.

Binds delta and mu opioid receptors with peripheral preference due to limited CNS penetration. Reduces gastric acid secretion, promotes mucosal blood flow, and inhibits ulcer formation via prostaglandin-mediated pathways.

A synthetic hexapeptide opioid analog with a leucine-enkephalin core extended by a C-terminal arginine. Developed in the Soviet Union for gastroprotective and analgesic applications. Studied for GI mucosal protection and pain modulation with peripheral preference.