Ac-SDKP vs Dalargin

Inhibits hematopoietic stem cell entry into S-phase. Blocks TGF-β1-mediated fibroblast activation, reducing collagen deposition. Promotes angiogenesis via VEGF upregulation. Regulated in vivo by ACE enzyme.

A naturally occurring tetrapeptide derived from thymosin beta-4 cleavage by prolyl oligopeptidase. Potent anti-fibrotic properties studied in cardiac, pulmonary, and renal fibrosis. Also promotes angiogenesis and wound healing.

Binds delta and mu opioid receptors with peripheral preference due to limited CNS penetration. Reduces gastric acid secretion, promotes mucosal blood flow, and inhibits ulcer formation via prostaglandin-mediated pathways.

A synthetic hexapeptide opioid analog with a leucine-enkephalin core extended by a C-terminal arginine. Developed in the Soviet Union for gastroprotective and analgesic applications. Studied for GI mucosal protection and pain modulation with peripheral preference.