About Palmitoyl Pentapeptide-4
Binds TGF-β receptors on fibroblasts, upregulating collagen I, III, fibronectin, and hyaluronic acid synthesis. The palmitoyl chain provides lipophilicity for improved skin penetration into the dermis.
A lipopeptide consisting of a palmitoyl fatty acid attached to the pentapeptide KTTKS. A key component of Matrixyl 3000 formulations. Stimulates collagen and extracellular matrix production more potently than palmitoyl tripeptide-1 (Matrixyl) alone, particularly for deep wrinkle reduction.
Research Areas
Regulatory & Evidence
Risk Profile
Generally considered lower risk in research contexts. Risk profile varies by individual — review contraindications before use.
Regulatory Status
- Availability Status
- Research Only
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Safety Notes
Generally considered lower risk in research contexts. Individual response varies — review all considerations before use.
Reported contraindications & considerations
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
Where to Find Palmitoyl Pentapeptide-4
2 providersTelehealth Platforms
1 providerClinics
1 providerFrequently Asked Questions — Palmitoyl Pentapeptide-4
A lipopeptide consisting of a palmitoyl fatty acid attached to the pentapeptide KTTKS. A key component of Matrixyl 3000 formulations.
collagen synthesis, wrinkle reduction, skin firmness, extracellular matrix support.
2 providers in the directory currently offer Palmitoyl Pentapeptide-4.