What is the difference between Follistatin 344 and Ipamorelin?

Follistatin 344: Binds and neutralizes myostatin (GDF-8) and activin; removes the natural brake on muscle growth allowing supraphysiological hypertrophy Ipamorelin: Ipamorelin binds to the ghrelin receptor (GHSR-1a) and stimulates dose-dependent GH release with a clean hormonal profile.

Is Follistatin 344 FDA approved?

Follistatin 344 is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Follistatin 344 administered in research settings?

In research settings, Follistatin 344 is typically administered via the intramuscular route. PeptideBase does not provide dosing or administration instructions.

How is Ipamorelin administered in research settings?

In research settings, Ipamorelin is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Follistatin 344 vs Ipamorelin

Peptide Comparison

Follistatin 344 vs Ipamorelin

Name: Follistatin 344 vs Ipamorelin — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Follistatin 344

FST-344

PerformanceNot EvaluatedResearch Only

Half-life: ~24-36 hours

15 providers listed

Full Follistatin 344 profile →

Ipamorelin

NNC 26-0161

PerformanceUnder clinical reviewResearch Only

Half-life: 2 hours

463 providers listed

Full Ipamorelin profile →

Bottom line

Follistatin 344 and Ipamorelin target different goals — Follistatin 344 for myostatin and activin A neutralization — dual TGF-β inhibition, Ipamorelin for selective GH release without cortisol or prolactin co-stimulation. They're compared here for reference, not as direct substitutes.

Quick Verdict

Follistatin 344

Half-life

~24-36 hours

Ipamorelin

Half-life

2 hours

Different Goals

Follistatin 344 and Ipamorelin target different goals — Follistatin 344 for Muscle & Myostatin, Ipamorelin for GH / IGF Axis. They're compared here for reference; there isn't a single “better” choice between them.

Side-by-Side Comparison

Follistatin 344

Ipamorelin

Mechanism Family

Muscle & Myostatin

GH / IGF Axis

Half-life

~24-36 hours

2 hours

FDA Status

not evaluated

Under clinical review

Admin Routes

intramuscular

subcutaneous

Availability

Research Only

Providers

15 listed

463 listed

FDA Update

—

Under clinical review

Avail. Notes

Myostatin inhibitor. No FDA approval. Gene therapy forms in early trials but recombinant protein is a research chemical. WADA prohibited. No NDA or IND for peptide form.

Selective GH secretagogue pentapeptide. Phase 2 by Helsinn (postoperative ileus) discontinued for lack of efficacy. No FDA approval. Not on FDA 503A bulks list. Research chemical.

Research Evidence

Follistatin 344

No citations on file

Ipamorelin

RCT · 5 key studies · most recent 2026

Research Citations

Follistatin 344

No citations on file.

Ipamorelin

RCT2014 · International Journal of Colorectal Disease

Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the managem…

Animal2000 · J Endocrinol

GH secretagogues increase bone mineral content in adult female rats

Review2026 · Int J Mol Sci

Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications…

Review2026 · JBJS Rev

Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Imp…

+1 more

About Follistatin 344

Binds and neutralizes myostatin (GDF-8) and activin; removes the natural brake on muscle growth allowing supraphysiological hypertrophy

Research Areas

myostatin and activin A neutralization — dual TGF-β inhibitionskeletal muscle hypertrophy in transgenic animal modelssatellite cell activation and muscle protein synthesis reliefgene therapy context: Becker MD phase 1/2a trial safety established

About Ipamorelin

Ipamorelin binds to the ghrelin receptor (GHSR-1a) and stimulates dose-dependent GH release with a clean hormonal profile. Unlike GHRP-6 or hexarelin, it does not significantly stimulate appetite-related pathways or cortisol secretion at standard research doses. This selectivity makes it a frequently studied peptide for protocols where hormonal side-effect profiles are a consideration.

Research Areas

selective GH release without cortisol or prolactin co-stimulationpulsatile GH secretion — synergistic with CJC-1295 in combination protocolslean mass support and fat metabolism via GH/IGF-1 axis modulationsubcutaneous injection 100–300 mcg; minimal receptor desensitization vs other GHRPs

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Follistatin 344

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Ipamorelin

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Suggested Monitoring

IGF-1Fasting glucoseHbA1cInsulin

Research protocols routinely measure IGF-1 to track GH axis activity before and during use. Fasting glucose and insulin are monitored because GH elevation can reduce insulin sensitivity over time.

Regulatory Notes

global — WADA

This compound falls under WADA Prohibited List category S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), prohibited at all times for competing athletes.

source

Used Together?

Ipamorelin

CJC-1295
Research suggests Ipamorelin and CJC-1295 may produce enhanced growth hormone release effects when combined. CJC-1295 provides sustained GHRH receptor stimulation while Ipamorelin provides pulsatile ghrelin receptor stimulation — complementary pathways studied in GH secretion research.
Sermorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.
GLP-1 agonists
Research notes metabolic pathway overlap between growth hormone-releasing peptides and GLP-1 agonists. Both compound classes influence metabolic signaling; limited research has studied their combined effects. Consult your prescriber before combining.

Price (per mg)

Follistatin 344

$102.67/mg

$90.00 – $139.00 range

12 vendors

View price index →Find providers →

Ipamorelin

$6.48/mg

$4.88 – $8.05 range

51 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Follistatin 344

15 listed

Browse directory →

Providers offering

Ipamorelin

463 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

Related Comparisons

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Educational research tools — not medical advice.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Follistatin 344 vs Ipamorelin — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/follistatin-344/ipamorelin

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