Peptide Profile
Splenin
Spleen peptide bioregulator · Lys-Glu-Asp-Gly
Splenin is a synthetic tripeptide (Lys-Glu-Asp, KED) classified as a Khavinson-class bioregulator peptide targeted at splenic and immune tissue, investigated for immunomodulatory and cytoprotective properties through proposed…
- Half-life
- Unknown
- Routes
- subcutaneous, intramuscular
Educational research information — not medical advice. Review primary sources and consult a qualified professional before any decision.
Educational research tools — not medical advice.
What Splenin is
About Splenin
Spleen-derived tetrapeptide bioregulator; normalizes leukocyte and platelet production; modulates splenic immune cell activity
Splenin is a synthetic tripeptide (Lys-Glu-Asp, KED) classified as a Khavinson-class bioregulator peptide targeted at splenic and immune tissue, investigated for immunomodulatory and cytoprotective properties through proposed gene expression regulatory mechanisms in lymphoid and hematopoietic cell populations. Like other short Khavinson bioregulator peptides, splenin is proposed to modulate gene expression in target immune cells via epigenetic mechanisms, with published research on the class demonstrating that ultrashort peptides can influence differentiation of stem and progenitor cells and regulate gene activity in aging tissues. Research on Khavinson-class ultrashort peptides has characterized neuroepigenetic mechanisms of action in neurodegeneration models and demonstrated peptide regulation of cell differentiation in stem cell preparations, providing the class-level mechanistic context within which splenin is proposed to act on immune tissue. Splenin has no FDA approval or regulatory approval in any major jurisdiction outside Russia; evidence derives from Khavinson-series preclinical and class-level studies with no independent clinical trials published in Western-indexed journals.
Splenin Benefits & Research Areas
Research Signals
Population research notes
These signals reflect research interest areas, not treatment indications.
What the evidence says about Splenin
Research Evidence
based on 2 studies · most recent 2022
Regulatory Status
- Availability Status
- Research Only
- FDA Status
- Not Evaluated
Russian peptide bioregulator from spleen (Khavinson Institute). Immunomodulatory. No FDA approval, no NDA or IND. Not on any FDA list. Research chemical in US only.
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Research Sources
2 sources cited · 2 weak
2 Reviews
Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease
International Journal of Molecular Sciences · 2022
This review examines proposed epigenetic mechanisms by which ultrashort peptides including Khavinson tissue-specific peptides such as splenin may exert neuroprotective effects through interactions with histone proteins, DNA regulatory elements, and non-coding RNAs, offering a hypothesis for peptide-based modulation of neuroinflammatory and neurodegenerative processes.
Peptide Regulation of Cell Differentiation
Stem Cell Reviews and Reports · 2020
This review summarizes evidence that short peptides of 2 to 7 amino acids regulate differentiation of immune, neural, epithelial, and stem cells by modulating histone accessibility, DNA methylation, and signaling pathway activation, providing a mechanistic framework for tissue-specific differentiation activity attributed to Khavinson peptides including splenin.
Splenin Side Effects & Safety Considerations
Research-use compound with limited human data. Evidence strength varies — see the Evidence section.
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
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Frequently Asked Questions — Splenin
Splenin is a synthetic tripeptide (Lys-Glu-Asp, KED) classified as a Khavinson-class bioregulator peptide targeted at splenic and immune tissue, investigated for immunomodulatory and cytoprotective properties through proposed gene expression regulatory mechanisms in lymphoid and hematopoietic cell populations. Like other short Khavinson bioregulator peptides, splenin is proposed to modulate gene expression in target immune cells via epigenetic mechanisms, with published research on the class demonstrating that ultrashort peptides can influence differentiation of stem and progenitor cells and regulate gene activity in aging tissues.
immune restoration, blood cell production, splenic function support.
Research on Splenin primarily documents effects related to immune restoration and blood cell production and splenic function support. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.
For Splenin, its FDA status is not evaluated by the FDA, and it is designated for research use only. Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
1 provider in the directory currently offers Splenin.
How to get Splenin
Where to buy Splenin
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Peptide Storage Guide
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