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CognitiveMedium Risk

TRH

Also known as: Thyrotropin-Releasing Hormone, Protirelin, Thyroliberin

Half-life:
~5-6 minutes

Administration Routes

intranasalintravenoussubcutaneous injection
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

Hypothalamic tripeptide (pGlu-His-Pro-NH2); binds TRH-R1/R2; stimulates TSH/prolactin release; direct CNS effects independent of thyroid axis including synaptic potentiation

The hypothalamic tripeptide that regulates thyroid function and has direct CNS effects. Shows antidepressant, neuroprotective, and cognitive-enhancing properties independent of its endocrine role.

Primary Research Areas

  • cognitive enhancement
  • neuroprotection
  • antidepressant
  • arousal/wakefulness

Risk Profile

Medium Risk

Moderate risk profile in research contexts. Consult a healthcare professional before use.

Regulatory Status

CompoundableNot Evaluated by FDA

Was FDA-approved as Thypinone (NDA 017812) and Relefact TRH for diagnostic TSH testing. Both products voluntarily discontinued. On FDA 503A Category 1 bulks list for compounding. Prescription.

Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

Where to Find TRH