About Angiotensin (1-7)
Binds Mas receptor (MasR), activating nitric oxide synthase and reducing oxidative stress. Opposes TGF-β and angiotensin II signaling to reduce fibrosis. Enhances insulin sensitivity and provides cardiovascular protection.
Angiotensin-(1-7) [Ang-(1-7)] is an endogenous heptapeptide hormone generated primarily through cleavage of angiotensin II by ACE2, functioning as a counter-regulatory arm of the renin-angiotensin system (RAS) by binding the Mas receptor to promote vasodilation, anti-fibrotic, anti-inflammatory, and cardioprotective effects that oppose the vasoconstrictive actions of angiotensin II. Ang-(1-7) acts through the ACE2/Mas receptor axis to reduce oxidative stress, attenuate NF-kB-mediated inflammation, and suppress TGF-beta fibrosis signaling; the ACE2/Ang-(1-7)/Mas axis has emerged as a key regulatory pathway in cardiovascular and metabolic disease, and gained renewed research attention given ACE2's role as the SARS-CoV-2 entry receptor. A Phase 1-2 randomized clinical trial of Ang-(1-7) infusion in COVID-19 ICU patients reported preliminary safety, tolerability, and dose-response data, providing the primary indexed human pharmacokinetic evidence; broader cardiovascular protective applications are supported by preclinical data but have not been established by completed Phase 3 trials. Ang-(1-7) has no FDA approval and no approved therapeutic indication in any jurisdiction; it is an endogenous peptide under active clinical investigation as a candidate for cardiovascular, metabolic, and inflammatory conditions, with emerging human safety data but an incomplete evidence base for any specific approved clinical use.
Angiotensin (1-7) Benefits & Research Areas
Regulatory & Evidence
Risk Profile
Generally considered lower risk in research contexts. Risk profile varies by individual — review contraindications before use.
Regulatory Status
- Availability Status
- Research Only
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Research Sources
6 sources cited · 6 moderate
1 RCT · 5 Cohorts
The Effect of Angiotensin (1-7) on Serum Metabolomics in Obese Type 2 Diabetic Mice.
Metabolites · 2026
# Summary Research found that Angiotensin (1-7) intervention in obese type 2 diabetic mice reduced blood glucose levels, decreased inflammatory markers, and improved lipid profiles while restoring pancreatic β-cell function. This study demonstrated that these metabolic improvements were associated with Angiotensin (1-7)'s regulatory effects on multiple pathways, including amino acid metabolism, lipid metabolism, insulin secretion, and cellular energy metabolism processes.
Pharmacological Effects of Angiotensin 1-7 on Venous Vascular Tone.
Biomedicines · 2026
# Summary Research found that Angiotensin (1-7) reduces contraction in venous tissue from rats primarily by activating potassium channels in the smooth muscle cells of blood vessel walls. This study demonstrated that the ACE2/Ang-(1-7)/Mas receptor pathway functions as a protective counter-regulatory mechanism in venous vessels, opposing the constricting effects of other vasoactive substances.
Perioperative Angiotensin-(1-7) for Postoperative Cognitive Vulnerability Following Coronary Artery Bypass Surgery: A Pilot Case Series.
Res Sq · 2026
# Summary Research found that Angiotensin-(1-7), a compound with neurovascular and anti-inflammatory properties, was feasible and well-tolerated when administered to older adults undergoing coronary artery bypass surgery, and showed preliminary signals of preserved cognitive function and reduced neuroaxonal injury markers compared to placebo. This pilot case series suggests that Angiotensin-(1-7) may warrant further investigation as a potential strategy to mitigate postoperative cognitive impairment following cardiac surgery.
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Differential Modulation of Spinal Angiotensin-Converting Enzymes Plays a Critical Role in the Development of Trigeminal Neuropathic Pain.
Pharmaceuticals (Basel) · 2026
# Summary Research found that nerve injury produces an imbalance in spinal angiotensin-converting enzymes, with increased ACE1 activity and decreased ACE2 activity in pain-processing regions of the spinal cord. This study demonstrated that restoring the ACE2 pathway and increasing angiotensin-(1-7) signaling through the Mas receptor reduced neuropathic pain in an animal model of trigeminal nerve injury, suggesting that modulating these enzyme systems may represent a novel therapeutic approach for chronic pain conditions.
Severe Acute Hypertension Causes Hemolysis With Release of PEP and ACE Inhibitor.
Hypertension · 2026
# Summary Research found that acute severe hypertension induced by angiotensin II injection causes intravascular hemolysis, which increases prolyl endopeptidase (PEP) activity and decreases angiotensin-converting enzyme (ACE) activity in plasma. This study demonstrated that these hemolysis-related enzyme changes enhance the conversion of angiotensin II to angiotensin-(1-7) while reducing angiotensin II formation, potentially influencing acute blood pressure regulation mechanisms.
Angiotensin-(1-7) improves oxygenation in mechanically ventilated COVID-19 patients: a randomized phase 1-2 seamless trial
Annals of Intensive Care · 2024
In a phase 1-2 seamless randomized trial of 107 mechanically ventilated COVID-19 patients, angiotensin-(1-7) 10 mcg/kg/day significantly increased oxygen-free days compared with controls (median 19 vs 14 days; p=0.04), supporting its role as a pulmonary protective and vasoactive agent in acute lung injury.
Angiotensin (1-7) Side Effects & Safety Considerations
Generally considered lower risk in research contexts. Individual response varies — review all considerations before use.
Reported contraindications & considerations
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
Where to Buy Angiotensin (1-7) — Providers & Availability
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Frequently Asked Questions — Angiotensin (1-7)
Angiotensin-(1-7) [Ang-(1-7)] is an endogenous heptapeptide hormone generated primarily through cleavage of angiotensin II by ACE2, functioning as a counter-regulatory arm of the renin-angiotensin system (RAS) by binding the Mas receptor to promote vasodilation, anti-fibrotic, anti-inflammatory, and cardioprotective effects that oppose the vasoconstrictive actions of angiotensin II. Ang-(1-7) acts through the ACE2/Mas receptor axis to reduce oxidative stress, attenuate NF-kB-mediated inflammation, and suppress TGF-beta fibrosis signaling; the ACE2/Ang-(1-7)/Mas axis has emerged as a key regulatory pathway in cardiovascular and metabolic disease, and gained renewed research attention given ACE2's role as the SARS-CoV-2 entry receptor.
cardiovascular protection, anti-fibrotic, vasodilation, insulin sensitivity, kidney protection.
Research on Angiotensin (1-7) primarily documents effects related to cardiovascular protection and anti-fibrotic and vasodilation and insulin sensitivity and kidney protection. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.
Reported contraindications and considerations for Angiotensin (1-7) include cardiovascular condition, kidney or liver condition, pregnant or nursing. This is educational information only — consult a qualified healthcare professional before use.
# Summary Research found that Angiotensin (1-7) intervention in obese type 2 diabetic mice reduced blood glucose levels, decreased inflammatory markers, and improved lipid profiles while restoring pancreatic β-cell function. This study demonstrated that these metabolic improvements were associated with Angiotensin (1-7)'s regulatory effects on multiple pathways, including amino acid metabolism, lipid metabolism, insulin secretion, and cellular energy metabolism processes.