What is the difference between Ipamorelin and Mod GRF 1-29?

Ipamorelin: Ipamorelin binds to the ghrelin receptor (GHSR-1a) and stimulates dose-dependent GH release with a clean hormonal profile. Mod GRF 1-29: Modified GHRH analog; binds GHRH receptors with improved stability to produce physiological GH pulses when combined with a GHRP

Is Ipamorelin FDA approved?

Ipamorelin is not FDA approved and restricted from compounding. It is discussed for research and educational purposes only, not as medical guidance.

Is Mod GRF 1-29 FDA approved?

Mod GRF 1-29 is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Ipamorelin administered in research settings?

In research settings, Ipamorelin is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

How is Mod GRF 1-29 administered in research settings?

In research settings, Mod GRF 1-29 is typically administered via the subcutaneous route. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Ipamorelin vs Mod GRF 1-29

Peptide Comparison

Ipamorelin vs Mod GRF 1-29

Name: Ipamorelin vs Mod GRF 1-29 — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are GH / IGF Axis peptides.

Ipamorelin

NNC 26-0161

PerformanceBanned from CompoundingResearch Only

Half-life: 2 hours

470 providers listed

Full Ipamorelin profile →

Mod GRF 1-29

CJC-1295 no DAC

PerformanceNot EvaluatedResearch Only

Half-life: ~30 minutes

15 providers listed

Full Mod GRF 1-29 profile →

Bottom line

Ipamorelin has a longer half-life than Mod GRF 1-29, so it generally needs less frequent dosing.

Quick Verdict

Ipamorelin

Evidence

Emerging Clinical

Half-life

2 hours

Mod GRF 1-29

Evidence

Emerging Clinical

Half-life

~30 minutes

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Ipamorelin
Less frequent dosing (longer half-life)	Ipamorelin
More provider options (470 vs 15)	Ipamorelin

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Ipamorelin

Mod GRF 1-29

Mechanism Family

GH / IGF Axis

Half-life

2 hours

~30 minutes

FDA Status

banned from compounding

not evaluated

Admin Routes

subcutaneous

Availability

Research Only

Providers

470 listed

15 listed

FDA Update

Sep 2023

—

Avail. Notes

Selective GH secretagogue pentapeptide. Phase 2 by Helsinn (postoperative ileus) discontinued for lack of efficacy. No FDA approval. Not on FDA 503A bulks list. Research chemical.

GHRH analog (CJC-1295 without DAC). Related to sermorelin but structurally distinct (tetrasubstituted AAs). No FDA approval. Not on FDA 503A bulks list. WADA prohibited. Research chemical.

Research Evidence

Ipamorelin

Emerging ClinicalRCT · 5 key studies · most recent 2026

Mod GRF 1-29

Emerging ClinicalRCT · 2 key studies · dated evidence base — most recent 1997

Research Citations

Ipamorelin

Review2026 · J Sports Med Phys Fitness

A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…

Review2026 · Int J Mol Sci

Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications…

Review2026 · JBJS Rev

Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Imp…

RCT2014 · International Journal of Colorectal Disease

Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the managem…

+1 more

Mod GRF 1-29

RCT1997 · Journal of Clinical Endocrinology and Metabolism

Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)…

RCT1997 · Journal of Clinical Endocrinology and Metabolism

Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune syst…

About Ipamorelin

Ipamorelin binds to the ghrelin receptor (GHSR-1a) and stimulates dose-dependent GH release with a clean hormonal profile. Unlike GHRP-6 or hexarelin, it does not significantly stimulate appetite-related pathways or cortisol secretion at standard research doses. This selectivity makes it a frequently studied peptide for protocols where hormonal side-effect profiles are a consideration.

Research Areas

selective GH release without cortisol or prolactin co-stimulationpulsatile GH secretion — synergistic with CJC-1295 in combination protocolslean mass support and fat metabolism via GH/IGF-1 axis modulationsubcutaneous injection 100–300 mcg; minimal receptor desensitization vs other GHRPs

About Mod GRF 1-29

Modified GHRH analog; binds GHRH receptors with improved stability to produce physiological GH pulses when combined with a GHRP

Research Areas

pituitary GHRH receptor agonism — pulsatile GH stimulationimproved proteolytic stability vs native GHRH 1-29synergistic GH release when combined with GHRPs (ipamorelin, GHRP-6)~30 min half-life — requires dosing at each session vs CJC-1295 with DAC (weekly)

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Ipamorelin

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Suggested Monitoring

IGF-1Fasting glucoseHbA1cInsulin

Research protocols routinely measure IGF-1 to track GH axis activity before and during use. Fasting glucose and insulin are monitored because GH elevation can reduce insulin sensitivity over time.

Regulatory Notes

global — WADA

This compound falls under WADA Prohibited List category S2 (Peptide Hormones, Growth Factors, Related Substances and Mimetics), prohibited at all times for competing athletes.

source

Mod GRF 1-29

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Used Together?

Commonly stacked

Well Documented

Ipamorelin and Mod GRF 1-29 are reported to work together. Research suggests Ipamorelin and Mod GRF 1-29 may produce enhanced growth hormone pulse effects when combined. Ipamorelin acts via ghrelin receptors (GHSR) while Mod GRF 1-29 acts via GHRH receptors — distinct pathways that research suggests may amplify GH secretion when activated together.

Ipamorelin

CJC-1295
Research suggests Ipamorelin and CJC-1295 may produce enhanced growth hormone release effects when combined. CJC-1295 provides sustained GHRH receptor stimulation while Ipamorelin provides pulsatile ghrelin receptor stimulation — complementary pathways studied in GH secretion research.
Mod GRF 1-29
Research suggests Ipamorelin and Mod GRF 1-29 may produce enhanced growth hormone pulse effects when combined. Ipamorelin acts via ghrelin receptors (GHSR) while Mod GRF 1-29 acts via GHRH receptors — distinct pathways that research suggests may amplify GH secretion when activated together.
Sermorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.

Mod GRF 1-29

Ipamorelin
Research suggests Ipamorelin and Mod GRF 1-29 may produce enhanced growth hormone pulse effects when combined. Ipamorelin acts via ghrelin receptors (GHSR) while Mod GRF 1-29 acts via GHRH receptors — distinct pathways that research suggests may amplify GH secretion when activated together.

Price (per mg)

Ipamorelin

$7.00/mg

$5.00 – $9.60 range

69 vendors

View price index →Find providers →

Mod GRF 1-29

$7.50/mg

$7.25 – $8.42 range

7 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Ipamorelin

470 listed

Browse directory →

Providers offering

Mod GRF 1-29

15 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More GH / IGF Axis Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated July 20, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Ipamorelin vs Mod GRF 1-29 — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/ipamorelin/mod-grf-1-29

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