Peptide Profile
Humanin
HN · MART
Humanin is a mitochondrially encoded 21-amino-acid peptide originally identified through its capacity to suppress neuronal apoptosis induced by familial Alzheimer's disease gene products, now recognized as a founding member of…
- Half-life
- ~2-4 hours
- Routes
- subcutaneous, intranasal
Educational research information — not medical advice. Review primary sources and consult a qualified professional before any decision.
Educational research tools — not medical advice.
What Humanin is
About Humanin
Mitochondria-derived peptide; binds gp130 receptor, activates STAT3/JAK pathway; inhibits BAX-mediated apoptosis; improves insulin sensitivity
Humanin is a mitochondrially encoded 21-amino-acid peptide originally identified through its capacity to suppress neuronal apoptosis induced by familial Alzheimer's disease gene products, now recognized as a founding member of the class of mitochondrial-derived peptides (MDPs) with broad cytoprotective actions in neurons, cardiomyocytes, and other metabolically stressed cell types. Humanin exerts its cytoprotective effects through multiple mechanisms: extracellularly, it binds insulin-like growth factor-binding protein 3 (IGFBP-3) to regulate IGFBP-3's interaction with nuclear import machinery and modulate its proapoptotic signaling; intracellularly, it inhibits c-Jun NH2-terminal kinase (JNK) activation through SH3-binding protein 5 to suppress stress-induced apoptotic cascades. PNAS research established that humanin interacts with IGFBP-3 to regulate cell survival and apoptosis, characterizing a molecular basis for its anti-apoptotic activity, and subsequent work identified JNK inhibition as an additional neuroprotective mechanism in humanin-treated neuronal preparations. Humanin is a research compound with no regulatory approval in any jurisdiction; published evidence is predominantly from in vitro and preclinical models, and no human clinical trials have been completed to establish pharmacokinetic, safety, or efficacy parameters for exogenous humanin administration.
Humanin Benefits & Research Areas
Research Signals
Commonly researched in the context of
Population research notes
These signals reflect research interest areas, not treatment indications.
Humanin half-life
Why no half-life is shown
Published half-life data for humanin is limited to animal studies and varies widely by analogue and species. No reliable human plasma half-life has been established.
What the evidence says about Humanin
Research Evidence
based on 5 studies · most recent 2026
Regulatory Status
- Availability Status
- Research Only
- FDA Status
- Not Evaluated
Mitochondria-derived 21-aa cytoprotective peptide encoded in 12S rRNA. No FDA approval, no NDA or IND. Research interest in aging and neuroprotection. Research use only.
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Research Sources
5 sources cited · 5 weak
5 Animals
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction.
Biomedicines · 2026
# Summary Research found that humanin and MOTS-c, mitochondrial-derived peptides that are reduced in atrial fibrillation patients, can attenuate the condition by suppressing atrial fibrosis, reducing mitochondrial dysfunction, and lowering inflammatory markers in mouse models. This study demonstrated that these peptides work through distinct mechanisms—humanin primarily via cell adhesion pathways and MOTS-c through metabolic processes—and showed an inverse correlation between peptide levels and disease severity in human AF patients.
Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
Toxicol Ind Health · 2026
# Summary Research found that Humanin, a mitochondrial peptide, protected PC12 cells from rotenone-induced damage by reducing reactive oxygen species formation through activation of the SIRT3/Nrf2/HO-1 signaling pathway. This study demonstrated that Humanin's protective mechanism involved increasing cellular antioxidant defenses and enhancing the cells' ability to counteract oxidative stress.
Humanin Restores Metabolic Hormone Homeostasis of Leptin, Ghrelin, Irisin and Asprosin in Streptozotocin-Induced Diabetic Mice.
Metabolites · 2026
Show 2 more sources ↓
Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats.
Res Sq · 2026
Humanin-G protects septic ARDS by mediating mitochondrial function in lung vascular endothelial cells.
Am J Respir Cell Mol Biol · 2026
# Summary Research found that Humanin-G (HNG), a mitochondrial peptide, protects lung blood vessel cells from damage in septic acute respiratory distress syndrome by restoring mitochondrial function and reducing inflammation through inhibition of the IL-6/STAT3 signaling pathway. This study demonstrated that HNG treatment reduced inflammatory markers, restored mitochondrial structure and energy production, and prevented cell death in both animal models and laboratory settings of septic ARDS.
Humanin Side Effects & Safety Considerations
Research-use compound with limited human data. Evidence strength varies — see the Evidence section.
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
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Frequently Asked Questions — Humanin
Humanin is a mitochondrially encoded 21-amino-acid peptide originally identified through its capacity to suppress neuronal apoptosis induced by familial Alzheimer's disease gene products, now recognized as a founding member of the class of mitochondrial-derived peptides (MDPs) with broad cytoprotective actions in neurons, cardiomyocytes, and other metabolically stressed cell types. Humanin exerts its cytoprotective effects through multiple mechanisms: extracellularly, it binds insulin-like growth factor-binding protein 3 (IGFBP-3) to regulate IGFBP-3's interaction with nuclear import machinery and modulate its proapoptotic signaling; intracellularly, it inhibits c-Jun NH2-terminal kinase (JNK) activation through SH3-binding protein 5 to suppress stress-induced apoptotic cascades.
neuroprotection, anti-apoptotic, metabolic improvement, cardiovascular protection.
Research on Humanin primarily documents effects related to neuroprotection and anti-apoptotic and metabolic improvement and cardiovascular protection. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.
For Humanin, its FDA status is not evaluated by the FDA, and it is designated for research use only. Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
9 providers in the directory currently offer Humanin.
Across 8 research vendors tracked on PeptideBase, Humanin has a median price of about $11.84 per mg, typically ranging $6.83–$14.60 per mg. This reflects research-use vendor pricing, not clinical or prescription costs.
How to get Humanin
Market Pricing
8 vendorsPrice per mg varies by quantity, vendor type, and formulation. Research use only.
Data verified August 2026 · Humanin price intelligence
Where to buy Humanin
9 providersClinics
7 providersDenver Wellness & Aesthetics Center
Englewood, United StatesView →Vital Infusions and Performance
Las Vegas, United StatesView →Maryland Trim Clinic
Laurel, United StatesView →Meeting Point Health
Philadelphia, United StatesView →The Hormone Zone
Scottsdale, United StatesView →Hormone & Peptide Therapy Greenville SC
Greenville, United StatesView →MATTR
Austin, United StatesView →
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Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Humanin — Per-mg Price Benchmark. Retrieved September 11, 2026, from https://peptidebase.io/peptides/humanin