LongevityLow Risk
Humanin
Also known as: HN, MART
- Half-life:
- ~2-4 hours
Administration Routes
subcutaneous injectionintranasal
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Mechanism of Action
Mitochondria-derived peptide; binds gp130 receptor, activates STAT3/JAK pathway; inhibits BAX-mediated apoptosis; improves insulin sensitivity
A mitochondria-derived peptide with cytoprotective effects throughout the body. Levels naturally decline with age; associated with longevity in centenarian offspring.
Primary Research Areas
- neuroprotection
- anti-apoptotic
- metabolic improvement
- cardiovascular protection
Risk Profile
Low Risk
Generally considered lower risk in research contexts. Consult a healthcare professional before use.
Regulatory Status
Research OnlyNot Evaluated by FDA
Mitochondria-derived 21-aa cytoprotective peptide encoded in 12S rRNA. No FDA approval, no NDA or IND. Research interest in aging and neuroprotection. Research use only.
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.