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LongevityLow Risk

MOTS-c

Also known as: Mitochondrial ORF of the 12S rRNA type-c

Half-life:
Unknown (rapidly cleared from plasma)

Administration Routes

subcutaneous injectionintravenous
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

Mitochondria-derived peptide that translocates to nucleus under stress; activates AMPK pathway, regulates AICAR and folate-methionine cycle

A mitochondria-derived peptide that acts as a metabolic regulator. Enhances insulin sensitivity, promotes fat burning, and may extend healthspan.

Primary Research Areas

  • metabolic regulation
  • insulin sensitivity
  • exercise mimicry
  • anti-aging

Risk Profile

Low Risk

Generally considered lower risk in research contexts. Consult a healthcare professional before use.

Regulatory Status

Research OnlyNot Evaluated by FDA

Mitochondria-derived peptide encoded in 12S rRNA. Regulates metabolism and exercise capacity. No FDA approval, no NDA or IND. Pure research compound; no clinical development program.

Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

Research Stacks

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Where to Find MOTS-c