About Vilon
Synthetic dipeptide Lys-Glu; modulates T-cell and NK cell activity; reduces age-related immune decline; normalizes cytokine production via epigenetic gene regulation
Vilon is a synthetic dipeptide (Lys-Glu, KE) classified as a Khavinson-class bioregulator originally derived from thymic tissue, proposed to modulate immune function in aging subjects by providing minimal thymic regulatory dipeptide signals that support T-lymphocyte activation and immune homeostasis diminished by age-related thymic involution. As the minimal active dipeptide unit of the Khavinson thymic bioregulator class, vilon is proposed to act through amino acid transporter uptake and modulation of intracellular signaling — including sphingomyelin pathway signal transduction in thymocytes — to restore T-cell activation thresholds and proliferative responses in immune cells from elderly subjects. Research has characterized natural and synthetic thymic peptides including vilon as therapeutic candidates for immune dysfunction, and experimental work has demonstrated that short Khavinson-class peptides modulate thymocyte blast transformation and sphingomyelin pathway signaling in immune cell preparations. Vilon has no FDA approval; evidence derives from Khavinson-series Russian preclinical and observational studies, and it has no regulatory approval in any major Western jurisdiction.
Vilon Benefits & Research Areas
Research Signals
Population research notes
These signals reflect research interest areas, not treatment indications.
Regulatory & Evidence
Risk Profile
Generally considered lower risk in research contexts. Risk profile varies by individual — review contraindications before use.
Regulatory Status
- Availability Status
- Research Only
- FDA Status
- Not Evaluated
Russian dipeptide bioregulator (Lys-Glu) from Khavinson Institute. Immunomodulatory and longevity research. Not FDA-approved. Not on any FDA list. Research chemical in US.
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Research Sources
2 sources cited · 2 moderate
1 Review · 1 Animal
Comparative study of the effects of vilon, epithalon, and cortagen on thymocyte proliferation and sphingomyelinase activity
Bulletin of Experimental Biology and Medicine · 2002
Research in mouse thymocyte cultures found that vilon produced the most potent comitogenic stimulation of thymocyte proliferation and sphingomyelinase activity compared with epithalon and cortagen, providing mechanistic evidence for its thymopoiesis-promoting activity and relevance to immune restoration in aging.
Immunomodulatory peptides from the thymus
International Journal of Immunopharmacology · 1997
This review describes the isolation of vilon (Lys-Glu) as the active immunomodulatory dipeptide from thymalin, documenting its activation of T-cell differentiation, cytokine regulatory activity, and comparison with thymogen, establishing it as the low-molecular-weight component responsible for thymalin's immune-modulating and geroprotective properties.
Vilon Side Effects & Safety Considerations
Generally considered lower risk in research contexts. Individual response varies — review all considerations before use.
Reported contraindications & considerations
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
Where to Buy Vilon — Providers & Availability
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Questions to Ask Your Provider
Frequently Asked Questions — Vilon
Vilon is a synthetic dipeptide (Lys-Glu, KE) classified as a Khavinson-class bioregulator originally derived from thymic tissue, proposed to modulate immune function in aging subjects by providing minimal thymic regulatory dipeptide signals that support T-lymphocyte activation and immune homeostasis diminished by age-related thymic involution. As the minimal active dipeptide unit of the Khavinson thymic bioregulator class, vilon is proposed to act through amino acid transporter uptake and modulation of intracellular signaling — including sphingomyelin pathway signal transduction in thymocytes — to restore T-cell activation thresholds and proliferative responses in immune cells from elderly subjects.
immune modulation, anti-aging, immune restoration, Longevity.
Research on Vilon primarily documents effects related to immune modulation and anti-aging and immune restoration and Longevity. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.
Reported contraindications and considerations for Vilon include none established. This is educational information only — consult a qualified healthcare professional before use.
2 providers in the directory currently offer Vilon.
Research in mouse thymocyte cultures found that vilon produced the most potent comitogenic stimulation of thymocyte proliferation and sphingomyelinase activity compared with epithalon and cortagen, providing mechanistic evidence for its thymopoiesis-promoting activity and relevance to immune restoration in aging.