Home›Research›Compare›Alpha-MSH vs CGRP
Peptide ComparisonAlpha-MSH vs CGRP
Alpha-MSH
Alpha-Melanocyte Stimulating Hormone
Half-life: ~3-5 minutes (plasma)
No providers listed yet
CGRP
Calcitonin Gene-Related Peptide
Half-life: ~3.6 min / ~13.6 min (biphasic; sheep)
2 providers listed
Alpha-MSH and CGRP target different goals — Alpha-MSH for anti-inflammatory, CGRP for Tissue Repair. They're compared here for reference, not as direct substitutes.
Alpha-MSH
Half-life
~3-5 minutes (plasma)
CGRP
Half-life
~3.6 min / ~13.6 min (biphasic; sheep)
Alpha-MSH and CGRP target different goals — Alpha-MSH for Reproductive & Hormonal, CGRP for Tissue Repair. They're compared here for reference; there isn't a single “better” choice between them.
Alpha-MSH
CGRP
Alpha-MSH
Preclinical assessment of (177)Lu-DOTA-Pip-Nle-CycMSH(hex): In vivo evaluation and human dosimetry estimation.
Antrodia cinnamomea extract exhibits anti-melanogenic and anti-photoaging effects: potential for cosmetic and…
Depigmenting Effects of Vitex rotundifolia Cone Essential Oil in Melanocytes and Its Chemical Composition.
Hypothalamic orexigenic and anorexigenic neuropeptides in the rotenone model of Parkinson's disease.
+8 more
CGRP
Efficacy and tolerability of erenumab in patients with episodic migraine in whom two-to-four previous prevent…
A Controlled Trial of Erenumab for Episodic Migraine
Three-year real-world effectiveness, treatment persistence, and planned discontinuation of anti-calcitonin ge…
Functional role of Nav1.8 channels in action potentials of mouse CGRP-lineage dorsal root ganglion neurons.
+6 more
About Alpha-MSH
Melanocortin peptide; activates MC1R (pigmentation/anti-inflammatory), MC3R (energy balance), MC4R (appetite); suppresses NF-κB and pro-inflammatory cytokines
About CGRP
Binds CLR/RAMP1 receptor complex. Causes vasodilation via cAMP/PKA/nitric oxide pathway. Modulates nociceptive signaling in the trigeminal system. Promotes bone healing and has anti-inflammatory effects in peripheral tissues.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Alpha-MSH
No established clinical contraindications
CGRP
No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.
Under clinical review
Being verified by our medical team before we display monitoring guidance for this peptide.
Where to source these peptides
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
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Browse all peptides →Educational research tools — not medical advice.