CGRP vs GLP-2

Binds CLR/RAMP1 receptor complex. Causes vasodilation via cAMP/PKA/nitric oxide pathway. Modulates nociceptive signaling in the trigeminal system. Promotes bone healing and has anti-inflammatory effects in peripheral tissues.

A 37-amino acid neuropeptide released from sensory nerve fibers and one of the most potent endogenous vasodilators. Central to migraine pathophysiology and studied for pain modulation, wound healing, and bone repair.

Binds GLP-2 receptor on intestinal enteroendocrine cells. Promotes enterocyte proliferation and reduces apoptosis, increasing villus height and crypt depth. Strengthens tight junctions and reduces intestinal permeability.

A 33-amino acid intestinal peptide co-secreted with GLP-1 from gut L-cells after eating. A potent intestinal trophic factor promoting gut lining integrity, villus growth, and reduced intestinal permeability. Studied for IBD, leaky gut, and gut repair.