What is the difference between Cortexin and Dihexa?

Cortexin: Polypeptide bioregulator from bovine cortex; modulates neurotransmitter activity; activates GABA and dopamine systems; reduces excitotoxicity; stimulates neuronal repair Dihexa: HGF/MET receptor potentiator; promotes new synapse formation; estimated 7 orders of magnitude more potent than BDNF in synaptogenesis models

Is Cortexin FDA approved?

Cortexin is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Cortexin administered in research settings?

In research settings, Cortexin is typically administered via the intramuscular route. PeptideBase does not provide dosing or administration instructions.

How is Dihexa administered in research settings?

In research settings, Dihexa is typically administered via the oral, transdermal, or subcutaneous routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Cortexin vs Dihexa

Peptide Comparison

Cortexin vs Dihexa

Both are Neuro & Cognitive peptides.

Cortexin

Cortexin-10

CognitiveNot EvaluatedResearch Only

Half-life: Unknown

4 providers listed

Full Cortexin profile →

Dihexa

PNB-0408

CognitiveResearch Only

Half-life: Unknown (likely days based on effects)

51 providers listed

Full Dihexa profile →

Bottom line

Dihexa is carried by more providers on PeptideBase (51 vs 4); otherwise the two are closely matched on the measures we track.

Quick Verdict

Cortexin

Dihexa

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Dihexa
Oral administration option	Dihexa
More provider options (4 vs 51)	Dihexa

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Cortexin

Dihexa

Mechanism Family

Neuro & Cognitive

Half-life

Unknown

Unknown (likely days based on effects)

FDA Status

not evaluated

nomination withdrawn

Admin Routes

intramuscular

oral, transdermal, subcutaneous

Availability

Research Only

Providers

4 listed

51 listed

Avail. Notes

Russian polypeptide preparation from cattle cerebral cortex. Registered in Russia for neurological conditions. No FDA approval, no NDA or IND, not on any FDA list. Research chemical in US.

Angiotensin IV-derived hexapeptide (PNB-0408) from WSU research. Cognitive enhancement in animal models. No FDA approval, no NDA or IND. Not on any FDA list. Research compound only.

Research Evidence

Cortexin

Review · 1 key study · dated evidence base — most recent 2013

Dihexa

Review · 2 key studies · dated evidence base — most recent 2002

Research Citations

Cortexin

Review2013 · Advances in gerontology

Neuroprotective effects of peptides bioregulators in people of various age

Dihexa

Animal2001 · Peptides

Angiotensin IV enhances LTP in rat dentate gyrus in vivo

Review2002 · Neuroscience and Biobehavioral Reviews

Neural plasticity and the brain renin-angiotensin system

About Cortexin

Polypeptide bioregulator from bovine cortex; modulates neurotransmitter activity; activates GABA and dopamine systems; reduces excitotoxicity; stimulates neuronal repair

Research Areas

neuroprotection and neuronal survival supportcognitive function improvement — documented in Russian clinical settingsantioxidant activity in CNS tissueEEG normalization and neurotrophic factor expression

About Dihexa

HGF/MET receptor potentiator; promotes new synapse formation; estimated 7 orders of magnitude more potent than BDNF in synaptogenesis models

Research Areas

HGF/MET receptor potentiation supporting synaptogenesishippocampal LTP enhancement in preclinical modelsmemory and neuroplasticity support (rodent data)no established human safety or pharmacokinetic profile

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Cortexin

Reported (Unverified — Pending Clinical Review)

bovine protein allergy

No established clinical contraindications

Dihexa

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Find Providers

Where to source these peptides

Providers offering

Cortexin

4 listed

Browse directory →

Providers offering

Dihexa

51 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

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Educational research tools — not medical advice.