EGF vs KGF-1

Binds EGFR (EGF receptor / ErbB1), activating RAS/MAPK and PI3K/Akt signaling cascades. Promotes keratinocyte and fibroblast proliferation, accelerates wound re-epithelialization, and stimulates collagen and hyaluronic acid production.

A 53-amino acid protein that potently stimulates cell proliferation and differentiation in epithelial and fibroblast cells. Widely used in aesthetic medicine for wound healing, skin regeneration, and post-procedure recovery. One of the most established growth factors in cosmetic dermatology.

Binds FGFR2b (the KGF receptor), which is exclusively expressed on epithelial cells — providing tissue-specific action without mesenchymal effects. Activates RAS/MAPK and PI3K/Akt to promote keratinocyte proliferation and migration. Extends the anagen phase of the hair growth cycle.

A member of the fibroblast growth factor family that specifically and exclusively targets epithelial cells via FGFR2b. A potent stimulator of keratinocyte proliferation with applications in wound healing, hair follicle growth, and mucosal repair.