Gonadorelin vs hCG

Synthetic GnRH that binds pituitary GnRH receptors; pulsatile dosing stimulates LH/FSH release; used to maintain HPG axis during TRT

Synthetic GnRH used to maintain pituitary-gonadal axis function, particularly during testosterone replacement therapy. Prevents testicular atrophy and preserves fertility.

Glycoprotein hormone binding LH receptor on Leydig cells; stimulates testosterone production; prevents testicular atrophy during TRT; maintains spermatogenesis via FSH-like activity

The most widely used adjunct in testosterone replacement therapy. Maintains testicular size and function, preserves fertility, and stimulates endogenous testosterone production by mimicking LH.