Home›Research›Compare›IGF-1 LR3 vs Sermorelin
Peptide ComparisonIGF-1 LR3 vs Sermorelin
Both are GH / IGF Axis peptides.
IGF-1 LR3
IGF1 LR3
Half-life: 20–30 hours
71 providers listed
Sermorelin
GHRH 1-29
Half-life: 10–20 minutes
449 providers listed
Sermorelin has published research citations on file; IGF-1 LR3 does not yet — the main evidence gap between them.
IGF-1 LR3
Half-life
20–30 hours
Sermorelin
Half-life
10–20 minutes
| Your goal | Better option |
|---|---|
| Has published research citations | Sermorelin |
| Less frequent dosing (longer half-life) | IGF-1 LR3 |
| More provider options (71 vs 449) | Sermorelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
IGF-1 LR3
Sermorelin
IGF-1 LR3
No citations on file.
Sermorelin
The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients…
The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostat…
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…
About IGF-1 LR3
Long-acting analog of IGF-1 that binds to IGF-1 receptors, promoting muscle protein synthesis, cellular growth, and recovery. Suppresses myostatin activity and has a significantly extended half-life compared to native IGF-1 due to reduced binding protein affinity.
About Sermorelin
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
IGF-1 LR3
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin clinical protocols measure IGF-1 as the primary marker of GH axis response. Fasting glucose and insulin are standard baseline assessments given GH's effect on insulin sensitivity.
Sermorelin
Ipamorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.
IGF-1 LR3
Not enough vendor pricing yet.
Sermorelin
Where to source these peptides
IGF-1 LR3
71 listed
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Providers offeringSermorelin
449 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.
Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). IGF-1 LR3 vs Sermorelin — Per-mg Price Comparison. Retrieved September 11, 2026, from https://peptidebase.io/peptides/compare/igf-1-lr3/sermorelin