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PerformanceLow Risk

Sermorelin

Also known as: GHRH 1-29, Sermorelin Acetate, Geref

Half-life:
10–20 minutes

Administration Routes

subcutaneous
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.

Sermorelin is a GHRH analogue used to stimulate endogenous growth hormone production. It is one of the most widely prescribed peptides in the anti-aging and functional medicine space, valued for preserving the natural pituitary feedback axis while supporting body composition, sleep quality, and tissue repair. Compounded formulations are available in the US through 503A pharmacies.

Primary Research Areas

  • performance
  • fat_loss
  • longevity

Risk Profile

Low Risk

Generally considered lower risk in research contexts. Consult a healthcare professional before use.

Providers Offering Sermorelin