What is the difference between Kisspeptin-10 and Melanotan II?

Kisspeptin-10: Activates GPR54/KISS1R receptor on GnRH neurons; triggers pulsatile GnRH release → LH/FSH surge → testosterone/estrogen production Melanotan II: Synthetic melanocortin receptor agonist (MC1R-MC5R); activates MC4R for erectile function/libido; MC1R for melanogenesis; MC3R for appetite suppression

Is Kisspeptin-10 FDA approved?

Kisspeptin-10 is not FDA approved and restricted from compounding. It is discussed for research and educational purposes only, not as medical guidance.

How is Kisspeptin-10 administered in research settings?

In research settings, Kisspeptin-10 is typically administered via the subcutaneous or intravenous routes. PeptideBase does not provide dosing or administration instructions.

How is Melanotan II administered in research settings?

In research settings, Melanotan II is typically administered via the subcutaneous or intranasal routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Kisspeptin-10 vs Melanotan II

Peptide Comparison

Kisspeptin-10 vs Melanotan II

Name: Kisspeptin-10 vs Melanotan II — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are Reproductive & Hormonal peptides.

Kisspeptin-10

KP-10

Sexual HealthBanned from CompoundingResearch Only

Half-life: ~4 minutes (3.8–4.1 min, human IV)

54 providers listed

Full Kisspeptin-10 profile →

Melanotan II

MT-II

Sexual HealthResearch Only

Half-life: ~1-2 hours

92 providers listed

Full Melanotan II profile →

Bottom line

Kisspeptin-10 carries stronger published evidence (RCT, 7 key studies) than Melanotan II (RCT, 2); both are research compounds.

Quick Verdict

Kisspeptin-10

Evidence

Clinical

Half-life

~4 minutes (3.8–4.1 min, human IV)

Melanotan II

Evidence

Emerging Clinical

Half-life

~1-2 hours

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Kisspeptin-10
Less frequent dosing (longer half-life)	Melanotan II
Lower typical price per mg	Melanotan II
More provider options (54 vs 92)	Melanotan II

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Kisspeptin-10

Melanotan II

Mechanism Family

Reproductive & Hormonal

Half-life

~4 minutes (3.8–4.1 min, human IV)

~1-2 hours

FDA Status

banned from compounding

nomination withdrawn

Admin Routes

subcutaneous, intravenous

subcutaneous, intranasal

Availability

Research Only

Providers

54 listed

92 listed

FDA Update

Sep 2023

—

Avail. Notes

No FDA approval. Phase 1/2 studies for hypogonadotropic hypogonadism and IVF trigger (NIH/academic). No NDA filed. Sold as research peptide outside of clinical trials.

Not FDA-approved. Not to be confused with bremelanotide (PT-141/Vyleesi, which is approved). No NDA. Sold illicitly as research chemical. FDA warns against injectable tanning products.

Research Evidence

Kisspeptin-10

ClinicalRCT · 7 key studies · most recent 2026

Melanotan II

Emerging ClinicalRCT · 2 key studies · dated evidence base — most recent 2014

Research Citations

Kisspeptin-10

Cohort2026 · Neuropeptides

Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmona…

Cohort2026 · Cytotechnology

Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory a…

Cohort2026 · Cytotechnology

Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory a…

Cohort2026 · Pharmacol Rep

Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.

+3 more

Melanotan II

Review2014 · Expert Opinion on Investigational Drugs

Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic re…

RCT2000 · Urology

Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with org…

About Kisspeptin-10

Activates GPR54/KISS1R receptor on GnRH neurons; triggers pulsatile GnRH release → LH/FSH surge → testosterone/estrogen production

Research Areas

GnRH neuron activation driving LH and FSH releaseovulation triggering studied in IVF clinical trialstestosterone and sperm production support in hypogonadotropic hypogonadismupstream HPG axis modulation above gonadorelin and hCG

About Melanotan II

Synthetic melanocortin receptor agonist (MC1R-MC5R); activates MC4R for erectile function/libido; MC1R for melanogenesis; MC3R for appetite suppression

Research Areas

central MC4R-mediated sexual arousal and erectile functionskin tanning via MC1R melanogenesis activationappetite suppression (MC4R hypothalamic pathway)significant side effect profile — nausea, flushing, pigmentation (vs cleaner successor PT-141)

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Kisspeptin-10

Reported (Unverified — Pending Clinical Review)

hormone-sensitive cancerspregnancy

No established clinical contraindications

Melanotan II

Warnings & Cautions

No FDA approval — investigationalMelanoma / dysplastic nevi — caution (melanocyte stimulation)Cardiovascular effectsPriapism (males)Known hypersensitivity

Class-based (investigational)

Used Together?

Melanotan II

Antihypertensive medications
Research notes that Melanotan II may influence cardiovascular function via melanocortin receptor activation. Combined use with antihypertensive medications may require blood pressure monitoring. Consult your prescriber before combining.

Price (per mg)

Kisspeptin-10

$6.00/mg

$5.00 – $8.15 range

10 vendors

View price index →Find providers →

Melanotan II

$4.50/mg

$3.70 – $6.00 range

60 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Kisspeptin-10

54 listed

Browse directory →

Providers offering

Melanotan II

92 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Reproductive & Hormonal Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated July 20, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Kisspeptin-10 vs Melanotan II — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/kisspeptin-10/melanotan-ii

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