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sexual_healthLow Risk

Kisspeptin-10

Also known as: KP-10, Metastin 45-54

Half-life:
~27 minutes

Administration Routes

subcutaneous injectionintravenous
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

Activates GPR54/KISS1R receptor on GnRH neurons; triggers pulsatile GnRH release → LH/FSH surge → testosterone/estrogen production

A naturally occurring neuropeptide that drives pulsatile GnRH release. Stimulates the HPG axis to increase testosterone and estrogen production; studied for hypogonadism and sexual dysfunction.

Primary Research Areas

  • LH surge
  • testosterone stimulation
  • libido enhancement
  • reproductive function

Risk Profile

Low Risk

Generally considered lower risk in research contexts. Consult a healthcare professional before use.

Regulatory Status

Research OnlyInvestigational

No FDA approval. Phase 1/2 studies for hypogonadotropic hypogonadism and IVF trigger (NIH/academic). No NDA filed. Sold as research peptide outside of clinical trials.

Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

Research Stacks

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Where to Find Kisspeptin-10