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Peptide Profile

Kisspeptin-10

Kisspeptin · KP-10 · Metastin 45-54

Kisspeptin-10 is a 10-amino-acid C-terminal fragment of the KISS1-derived peptide family, which serves as the primary upstream regulator of GnRH pulsatility in the hypothalamus. By binding to the KISS1R receptor on GnRH neurons,…

Reproductive & HormonalUnder clinical reviewResearch Only
Used forsexual health
Half-life
~4 minutes (3.8–4.1 min, human IV)
Routes
subcutaneous, intravenous
Find providers View evidence

Educational research information — not medical advice. Review primary sources and consult a qualified professional before any decision.

Educational research tools — not medical advice.

Overview

What Kisspeptin-10 is

About Kisspeptin-10

Activates GPR54/KISS1R receptor on GnRH neurons; triggers pulsatile GnRH release → LH/FSH surge → testosterone/estrogen production

Kisspeptin-10 is a 10-amino-acid C-terminal fragment of the KISS1-derived peptide family, which serves as the primary upstream regulator of GnRH pulsatility in the hypothalamus. By binding to the KISS1R receptor on GnRH neurons, kisspeptin-10 triggers GnRH release and downstream LH and FSH secretion, positioning it as a master regulator of the reproductive neuroendocrine axis. Peer-reviewed human studies demonstrate that kisspeptin administration evokes LH pulse generation and modulates gonadotropin secretion in both healthy volunteers and individuals with reproductive dysfunction, including polycystic ovary syndrome. Kisspeptin-10 is an investigational peptide actively studied in clinical research; it is not approved by the FDA for any therapeutic indication and is not available as a licensed pharmaceutical. Kisspeptin-10 research contexts: clinical studies at Imperial College London and other institutions have characterized kisspeptin-10 pharmacology in human subjects across multiple reproductive contexts. In women, kisspeptin administration has been studied for ovulation triggering in IVF protocols as an alternative to hCG, with phase 2 trial data supporting its effectiveness for oocyte maturation while potentially reducing ovarian hyperstimulation syndrome risk. In men with hypogonadotropic hypogonadism, kisspeptin-10 infusion protocols have been studied to characterize LH pulse deficits and assess reproductive axis recovery. The peptide's upstream position in the GnRH axis — above gonadorelin, hCG, and downstream gonadotropins — makes it a research tool for understanding the root causes of hypothalamic-level reproductive dysfunction. Kisspeptin-10 vs kisspeptin-54: the two forms differ in length and pharmacokinetic profile. Kisspeptin-54 is the full 54-amino-acid peptide with a longer half-life in circulation; kisspeptin-10 is the truncated, most biologically active fragment. Human studies have used both forms depending on the research objective — kisspeptin-10 for acute LH pulse characterization, kisspeptin-54 for sustained gonadotropin studies. Neither is commercially available as an approved therapeutic. Fertility-focused telehealth providers and reproductive hormone specialists are listed in the PeptideBase directory.

Women's Health

Subcutaneous kisspeptin-54 has been studied in Phase 2 randomized controlled trials as an oocyte-maturation trigger during IVF, with a favorable OHSS-risk profile relative to hCG triggers, but remains investigational and is not FDA-approved for this or any indication. Chronic/repeated kisspeptin administration causes receptor tachyphylaxis in controlled human dosing studies, so it is not evidenced as a cycle-restoring or fertility-maintenance therapy. Kisspeptin's role in menopause and pregnancy/lactation is mechanistic only — no human administration-safety data exist for either context.

Kisspeptin-10 Benefits & Research Areas

GnRH neuron activation driving LH and FSH releaseovulation triggering studied in IVF clinical trialstestosterone and sperm production support in hypogonadotropic hypogonadismupstream HPG axis modulation above gonadorelin and hCG

Research Signals

Commonly researched in the context of

Hormonal Changes

Population research notes

30s40s50+

These signals reflect research interest areas, not treatment indications.

Pharmacokinetics

Kisspeptin-10 half-life calculator

Compound & timing

Half-lifefrom PeptideBase data
Source: "~4 minutes (3.8–4.1 min, human IV)" · Kisspeptin-10 (PeptideBase)
to show amount remaining
4 min
0%25%50%75%100%04.28.3121721time since dose (min)
Plasma decay curve for Kisspeptin-10: 50% remaining at 4 min after the dose.
plasma level
50%remaining in plasmaat 4 min after the dose
Half-life
4 min
~97% cleared after
20 min

Model: single-dose, first-order (single-compartment) estimate. Real clearance is multi-compartment and varies by individual and route.

The Research

What the evidence says about Kisspeptin-10

Research Evidence

based on 6 studies · 1 RCT · most recent 2026

Regulatory Status

Availability Status
Research Only
FDA Status
Under clinical review
Source
View FDA source →

No FDA approval. Phase 1/2 studies for hypogonadotropic hypogonadism and IVF trigger (NIH/academic). No NDA filed. Sold as research peptide outside of clinical trials.

Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

Research Sources

6 sources cited · 1 strong · 5 weak

1 RCT · 2 Reviews · 1 Animal · 2 In vitros

  • Kisspeptin and neurokinin B interactions in modulating gonadotropin secretion in women with polycystic ovary syndrome

    Human Reproduction · 2020

    Research in a randomized trial of 15 women with PCOS found that a 7-day NK3 receptor antagonist course reduced LH pulse frequency (0.5 vs 0.8 pulses/h, p<0.05) and LH/FSH secretion, while the stimulatory LH response to kisspeptin-10 infusion was preserved, demonstrating the distinct and interactive roles of kisspeptin-10 and neurokinin B in regulating GnRH secretion in the context of PCOS.

    RCTn=15StrongPMID 32510130

  • Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells.

    Neuropeptides · 2026

    # Summary Research found that Kisspeptin-10, working through the GPR54 receptor, significantly reduced pulmonary arterial hypertension in a mouse model by restoring proper mitochondrial function and reducing excessive mitophagy in pulmonary artery smooth muscle cells. This study demonstrated that the Kisspeptin/GPR54 signaling pathway represents a potential therapeutic target for treating pulmonary arterial hypertension.

    AnimalWeakPMID 41955717

  • Exogenous Kisspeptin-10 inhibits ovarian cancer progression through targeting the SP1-hTERT-ZEB1 regulatory axis.

    Cytotechnology · 2026

    In vitroWeakPMID 42292313
Show 3 more sources ↓

  • Kisspeptin-10 regulates glycosaminoglycan and decorin content in human cardiac fibroblast cultures.

    Pharmacol Rep · 2026

    # Summary This study demonstrated that kisspeptin-10 increased glycosaminoglycan and decorin content in human cardiac fibroblast cultures through a signaling pathway involving GPR54 activation and FAK signaling. Researchers observed that these regulatory effects on extracellular matrix components suggest kisspeptin-10 may play a role in cardiac extracellular matrix remodeling.

    In vitroWeakPMID 42159865

  • The KISS1/KISS1R Axis in Human Placentation: Molecular Mechanisms and Implications for Foetal Growth Restriction and Pre-Eclampsia.

    Int J Mol Sci · 2026

    # Summary Research found that Kisspeptin-10 (KP-10) signaling through its receptor KISS1R plays a key role in regulating placental development and vascular adaptation, with reduced maternal circulating kisspeptin levels associated with pregnancy complications including fetal growth restriction and pre-eclampsia. This study demonstrated that dysregulation of the KISS1/KISS1R axis—which controls trophoblast invasion, angiogenic balance, and spiral artery transformation—represents an early molecular disturbance in placental dysfunction, though methodological inconsistencies across existing research limit definitive clinical conclusions about its biomarker utility.

    ReviewTheoreticalPMID 42123334

  • The roles of kisspeptin and neurokinin B in GnRH pulse generation in humans, and their potential clinical application

    Journal of Neuroendocrinology · 2021

    This review of clinical studies in men and women found that continuous infusion of kisspeptin-10 at receptor-saturating levels increased LH (GnRH) pulse frequency across multiple conditions including healthy volunteers, hypogonadal subjects, PCOS, and those with NKB pathway mutations, without receptor desensitization over 22 hours, establishing kisspeptin-10 as a potent and sustained activator of the HPG axis.

    ReviewTheoreticalPMID 34962670

Kisspeptin-10 Side Effects & Safety Considerations

Research-use compound with limited human data. Evidence strength varies — see the Evidence section.

Reported (unverified — pending clinical review)

hormone-sensitive cancerspregnancy

No established clinical contraindications

Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.

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Kisspeptin-10

Third-party testing data

Limited testing data (2 verified results)

We only show a verified-testing signal once at least 3 independent lab results are on file. Below that, we show what we have without implying a confidence signal.

PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Certificates of Analysis

Cross-vendor verified13 COAs on record for Kisspeptin-10

PeptideBase reports these lab-published figures and does not itself test, endorse, or certify any product. Confirmed by lab results were matched against the issuing laboratory's own records — either the lab served the document, or its own hosted copy matches ours byte for byte. For every other result the badge states what is known about the lab: that it can be checked and no result is recorded yet, that it can't be checked, or that we have not reviewed it.

PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Frequently Asked Questions — Kisspeptin-10

Kisspeptin-10 is a 10-amino-acid C-terminal fragment of the KISS1-derived peptide family, which serves as the primary upstream regulator of GnRH pulsatility in the hypothalamus. By binding to the KISS1R receptor on GnRH neurons, kisspeptin-10 triggers GnRH release and downstream LH and FSH secretion, positioning it as a master regulator of the reproductive neuroendocrine axis.

GnRH neuron activation driving LH and FSH release, ovulation triggering studied in IVF clinical trials, testosterone and sperm production support in hypogonadotropic hypogonadism, upstream HPG axis modulation above gonadorelin and hCG.

Research on Kisspeptin-10 primarily documents effects related to GnRH neuron activation driving LH and FSH release and ovulation triggering studied in IVF clinical trials and testosterone and sperm production support in hypogonadotropic hypogonadism and upstream HPG axis modulation above gonadorelin and hCG. These are areas covered in preclinical and clinical literature — individual response varies and effects depend on context of use.

Reported contraindications and considerations for Kisspeptin-10 include hormone-sensitive cancers, pregnancy. This is educational information only — consult a qualified healthcare professional before use.

For Kisspeptin-10, it is designated for research use only. Regulatory status reflects publicly available information and may change. This is not legal or medical advice.

42 providers in the directory currently offer Kisspeptin-10.

Across 40 research vendors tracked on PeptideBase, Kisspeptin-10 has a median price of about $5.85 per mg, typically ranging $4.50–$8.00 per mg. This reflects research-use vendor pricing, not clinical or prescription costs.

Research in a randomized trial of 15 women with PCOS found that a 7-day NK3 receptor antagonist course reduced LH pulse frequency (0.5 vs 0.8 pulses/h, p<0.05) and LH/FSH secretion, while the stimulatory LH response to kisspeptin-10 infusion was preserved, demonstrating the distinct and interactive roles of kisspeptin-10 and neurokinin B in regulating GnRH secretion in the context of PCOS.

Kisspeptin-10 is featured in the following research stacks on PeptideBase: PT-141 + Kisspeptin-10: Sexual Health.

Access

How to get Kisspeptin-10

Market Pricing

40 vendors
$4.50/mgBudget
$5.85/mgMedian
$8.00/mgPremium
$4.50
$5.85
$8.00

Price per mg varies by quantity, vendor type, and formulation. Research use only.

Data verified August 2026 · Kisspeptin-10 price intelligence

Compare 40 vendors →
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Where to buy Kisspeptin-10

42 providers
●34 Clinics●8 Online Vendors53 in stock
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Research stacks

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Commonly stacked with

PT-141

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Tools & Guides

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Convert vial size + BAC water volume into draw volume.

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Step-by-step guide: BAC water, vial prep, and storage after mixing.

Peptide Dosage Guide

Key factors that determine dosing in clinical practice.

Peptide Storage Guide

How to store lyophilized and reconstituted peptides.

Cite this page

Data last updated August 26, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Kisspeptin-10 — Per-mg Price Benchmark. Retrieved September 11, 2026, from https://peptidebase.io/peptides/kisspeptin-10
https://peptidebase.io/peptides/kisspeptin-10MethodologyLicenseDownload JSONDownload CSV

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