Leuprolide vs LH

Continuous GnRH receptor stimulation causes receptor desensitization and downregulation. This suppresses LH/FSH → testosterone/estrogen to castrate levels. Short-term pulsatile use can transiently stimulate the axis before suppression occurs.

A synthetic GnRH agonist that paradoxically suppresses gonadotropin release with continuous administration via receptor downregulation. FDA-approved for prostate cancer, endometriosis, and uterine fibroids. Used off-label in men's health for HPG axis restart protocols.

Binds LH receptors on testicular Leydig cells, stimulating the cholesterol → testosterone biosynthetic pathway. In women, the LH surge triggers ovulation and supports luteal phase progesterone production.

A pituitary gonadotropin that drives testosterone production in men by stimulating Leydig cells, and triggers ovulation in women. Used in fertility protocols and studied for natural HPG axis support alongside FSH and hCG.