Educational use only — not medical advice
Research library
Leuprolide benefits
From the PeptideBase research library. Educational only — not medical advice.
Studied effects
- HPG axis modulation
- testosterone suppression
- hormonal restart
- GnRH axis control
Mechanism
Continuous GnRH receptor stimulation causes receptor desensitization and downregulation. This suppresses LH/FSH → testosterone/estrogen to castrate levels. Short-term pulsatile use can transiently stimulate the axis before suppression occurs.