AICAR

Berberine Regulates Hepatic Fatty Acid Metabolism via AMPK/SIRT1/PGC-1α Pathway.

Chin J Integr Med · 2026

# Summary Research found that berberine regulates hepatic fatty acid metabolism and reduces liver lipid accumulation through activation of the AMPK/SIRT1/PGC-1α signaling pathway. This study demonstrated that berberine's effects involve modulating the expression of proteins involved in fatty acid transport, synthesis, and breakdown, with results suggesting potential therapeutic relevance for non-alcoholic fatty liver disease concurrent with type 2 diabetes.

Pharmacological inhibition of TRPM4 channel stabilizes atherosclerotic plaque via inhibiting AMPK-Beclin1-mediated autophagy.

Eur J Pharmacol · 2026

# Summary Research found that AICAR, an AMPK agonist, reversed the protective effects of TRPM4 inhibition against excessive autophagy and apoptosis in endothelial cells exposed to oxidized low-density lipoprotein. This study demonstrated that AICAR's activation of the AMPK signaling pathway could counteract the beneficial cellular responses achieved through TRPM4 channel inhibition in the atherosclerotic disease model.

MiR-27b-3p suppresses proliferation and testosterone synthesis in goat Leydig cells by activating the AMPK pathway through PPARG targeting.

Anim Reprod Sci · 2026

# Summary Research found that miR-27b-3p suppresses Leydig cell proliferation and testosterone synthesis by targeting PPARG, which in turn regulates AMPK signaling. This study demonstrated that activating AMPK through this regulatory pathway can partially restore cellular functions impaired by PPARG suppression, revealing a molecular mechanism relevant to testicular development and reproductive function in male goats.

Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress.

Equine Vet J · 2026

# Summary Research found that adiponectin receptor agonists, including AICAR, reduced endoplasmic reticulum stress markers in equine lamellar cells exposed to chemical stressors. This study demonstrated that these compounds decreased expression of stress-response proteins and inflammatory markers, suggesting a potential protective mechanism relevant to laminitis pathophysiology.

Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT.

Biomed Opt Express · 2026

Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by CLN3 deficiency and alleviated by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in human ARPE-19 cells.

Biochem Biophys Res Commun · 2026

The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)(3) exposure in HT22 hippocampal neuronal cells.

Free Radic Biol Med · 2026

Neuroprotective effects of Platycladus orientalis ethyl acetate fraction on retinal Müller cells: modulation of AKT1/mTOR and Raf-1/MEK1/2 pathways via AMPK activation.

Front Mol Biosci · 2026

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

Diabetologia · 2008

Research in a crossover clinical trial found that intravenous AICAR administration activated the AMPK pathway, reduced hepatic glucose output, and decreased circulating free fatty acids in male patients with type 2 diabetes, demonstrating in vivo AMPK activation as a metabolic regulatory mechanism.