What is the difference between Cortagen and Glutathione?

Cortagen: Brain cortex-derived tetrapeptide that modulates gene expression in neural and cardiac tissue through chromatin regulatory mechanisms; Glutathione: Master endogenous antioxidant tripeptide; neutralizes ROS, regenerates vitamins C and E, supports phase II liver detoxification, maintains intracellular redox balance

Is Cortagen FDA approved?

Cortagen is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

Is Glutathione FDA approved?

Glutathione is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Cortagen administered in research settings?

In research settings, Cortagen is typically administered via the oral or subcutaneous routes. PeptideBase does not provide dosing or administration instructions.

How is Glutathione administered in research settings?

In research settings, Glutathione is typically administered via the intravenous, subcutaneous, oral (liposomal), nebulized, or oral routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Cortagen vs Glutathione

Peptide Comparison

Cortagen vs Glutathione

Name: Cortagen vs Glutathione — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are Longevity & Cellular peptides.

Cortagen

vascular peptide bioregulator

LongevityNot EvaluatedResearch Only

No providers listed yet

Full Cortagen profile →

Glutathione

GSH

RecoveryNot EvaluatedCompoundable

Half-life: Variable (~2-5 minutes IV; hours liposomal)

133 providers listed

Full Glutathione profile →

Bottom line

Glutathione carries stronger published evidence (RCT, 3 key studies) than Cortagen (Review, 2); both are research compounds.

Quick Verdict

Cortagen

Evidence

Preclinical

Half-life

—

Glutathione

Evidence

Clinical

Half-life

Variable (~2-5 minutes IV; hours liposomal)

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Glutathione
Lower typical price per mg	Glutathione
More provider options (0 vs 133)	Glutathione

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Cortagen

Glutathione

Mechanism Family

Longevity & Cellular

Half-life

—

Variable (~2-5 minutes IV; hours liposomal)

FDA Status

not evaluated

Admin Routes

oral, subcutaneous

intravenous, subcutaneous, oral (liposomal), nebulized, oral

Availability

Research Only

Compoundable

Providers

None listed

133 listed

Avail. Notes

—

On FDA 503A Category 1 bulk drug substances list for injectable/IV compounding. Also sold as dietary supplement. Not FDA-approved as standalone drug. Compoundable by licensed 503A pharmacies.

Research Evidence

Cortagen

PreclinicalReview · 2 key studies · most recent 2021

Glutathione

ClinicalRCT · 3 key studies · most recent 2026

Research Citations

Cortagen

Review2021 · Molecules

Peptide Regulation of Gene Expression: A Systematic Review

Animal2004 · Neuroendocrinology Letters

The effect of short peptides on the expression of genes in the cardiac muscle of old male rats

Glutathione

Cohort2026 · BMC Psychiatry

Neuroinflammatory-related biomarkers and psychiatric symptom changes in substance use disorder: a South Afric…

RCT2009 · Movement Disorders

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

RCT1992 · European Journal of Clinical Pharmacology

The systemic availability of oral glutathione

About Cortagen

Brain cortex-derived tetrapeptide that modulates gene expression in neural and cardiac tissue through chromatin regulatory mechanisms; microarray analysis demonstrates broad transcriptional effects following administration.

Research Areas

neuroprotectiongene expression regulationlongevityanti-aging

About Glutathione

Master endogenous antioxidant tripeptide; neutralizes ROS, regenerates vitamins C and E, supports phase II liver detoxification, maintains intracellular redox balance

Research Areas

intracellular redox homeostasis and ROS scavengingIV administration bypasses oral bioavailability failure — acute plasma GSH elevationmelanin synthesis modulation studied for skin pigmentation (mixed evidence)glutathione peroxidase substrate — core detoxification pathway cofactor

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Cortagen

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Glutathione

Reported (Unverified — Pending Clinical Review)

asthma (nebulized form)

No established clinical contraindications

Price (per mg)

Cortagen

$2.75/mg

$2.50 – $3.11 range

5 vendors

View price index →Find providers →

Glutathione

$0.04/mg

$0.04 – $0.07 range

29 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Cortagen

Browse directory →

Providers offering

Glutathione

133 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Longevity & Cellular Comparisons

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Educational research tools — not medical advice.

Cite this page

Data last updated July 22, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Cortagen vs Glutathione — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/cortagen/glutathione

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