Cortagen vs Epithalon

Vascular-targeted peptide complex that modulates endothelial cell gene expression. May support nitric oxide production, reduce vascular inflammation, and improve endothelial function.

A short peptide bioregulator derived from blood vessel tissue, developed by the Khavinson Institute. Studied for cardiovascular function support and mitigation of age-related vascular deterioration.

Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. It also appears to regulate the expression of p53 and other cell-cycle control genes, modulate the hypothalamic-pituitary axis via pineal gland activity, and upregulate antioxidant defences including superoxide dismutase and catalase.

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research into the pineal gland peptide complex epithalamin. It is researched for its role in regulating melatonin secretion, antioxidant enzyme activity, and telomere dynamics, with a body of work primarily from Russian research groups.