What is the difference between Cortexin and VIP?

Cortexin: Polypeptide bioregulator from bovine cortex; modulates neurotransmitter activity; activates GABA and dopamine systems; reduces excitotoxicity; stimulates neuronal repair VIP: Pleiotropic neuropeptide binding VPAC1/VPAC2 receptors; suppresses neuroinflammation, regulates circadian rhythm via SCN, modulates immune response

Is Cortexin FDA approved?

Cortexin is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

VIP is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is Cortexin administered in research settings?

In research settings, Cortexin is typically administered via the intramuscular route. PeptideBase does not provide dosing or administration instructions.

How is VIP administered in research settings?

In research settings, VIP is typically administered via the intranasal or intravenous routes. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›Cortexin vs VIP

Peptide Comparison

Cortexin vs VIP

Name: Cortexin vs VIP — Per-mg Price Comparison
Creator: PeptideBase
License: https://peptidebase.io/terms

Both are Neuro & Cognitive peptides.

Cortexin

Cortexin-10

CognitiveNot EvaluatedResearch Only

Half-life: Unknown

4 providers listed

Full Cortexin profile →

VIP

Vasoactive Intestinal Peptide

CognitiveNot EvaluatedResearch Only

Half-life: ~1-2 minutes (plasma)

22 providers listed

Full VIP profile →

Bottom line

Cortexin carries stronger published evidence (RCT, 2 key studies) than VIP (Review, 2); both are research compounds.

Quick Verdict

Cortexin

Evidence

Emerging Clinical

Half-life

Unknown

VIP

Evidence

Preclinical

Half-life

~1-2 minutes (plasma)

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	Cortexin
More provider options (4 vs 22)	VIP

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

Cortexin

VIP

Mechanism Family

Neuro & Cognitive

Half-life

Unknown

~1-2 minutes (plasma)

FDA Status

not evaluated

Admin Routes

intramuscular

intranasal, intravenous

Availability

Research Only

Providers

4 listed

22 listed

Avail. Notes

Russian polypeptide preparation from cattle cerebral cortex. Registered in Russia for neurological conditions. No FDA approval, no NDA or IND, not on any FDA list. Research chemical in US.

Endogenous 28-aa neuropeptide. No FDA-approved product. Inhaled VIP studied in Phase 2 for pulmonary arterial hypertension (Santhera); program not advanced. No NDA filed. Research use only.

Research Evidence

Cortexin

Emerging ClinicalRCT · 2 key studies · most recent 2019

VIP

PreclinicalReview · 2 key studies · most recent 2022

Research Citations

Cortexin

RCT2019 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

Evaluation of the efficacy and safety of cortexin in the complex rehabilitation of verticalization in patient…

Review2013 · Advances in gerontology

Neuroprotective effects of peptides bioregulators in people of various age

VIP

In vitro2022 · Journal of Molecular Neuroscience

PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells

Review2017 · Mediators of Inflammation

Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases

About Cortexin

Polypeptide bioregulator from bovine cortex; modulates neurotransmitter activity; activates GABA and dopamine systems; reduces excitotoxicity; stimulates neuronal repair

Research Areas

neuroprotection and neuronal survival supportcognitive function improvement — documented in Russian clinical settingsantioxidant activity in CNS tissueEEG normalization and neurotrophic factor expression

About VIP

Pleiotropic neuropeptide binding VPAC1/VPAC2 receptors; suppresses neuroinflammation, regulates circadian rhythm via SCN, modulates immune response

Research Areas

neuroprotectionanti-inflammatory (CNS)CIRS treatmentcircadian rhythm regulation

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

Cortexin

Reported (Unverified — Pending Clinical Review)

bovine protein allergy

No established clinical contraindications

VIP

Reported (Unverified — Pending Clinical Review)

low blood pressurevasoactive drug interactions

No established clinical contraindications

Price (per mg)

Cortexin

Not enough vendor pricing yet.

VIP

$5.50/mg

$4.00 – $8.00 range

9 vendors

View price index →Find providers →

Find Providers

Where to source these peptides

Providers offering

Cortexin

4 listed

Browse directory →

Providers offering

VIP

22 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Neuro & Cognitive Comparisons

Browse all peptides →

Educational research tools — not medical advice.

Cite this page

Data last updated July 20, 2026

Free to reference and republish with attribution to PeptideBase. Choose a format:

PeptideBase. (2026). Cortexin vs VIP — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/cortexin/vip

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