Endoluten vs Epithalon

Pineal-targeted peptide complex that modulates melatonin synthesis pathways and circadian gene expression. May help restore age-related decline in pineal activity and improve circadian rhythm regulation.

A short peptide bioregulator derived from pineal gland tissue, developed by the Khavinson Institute. Studied for circadian rhythm restoration, melatonin pathway support, and longevity — addressing the age-related decline in pineal gland function.

Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. It also appears to regulate the expression of p53 and other cell-cycle control genes, modulate the hypothalamic-pituitary axis via pineal gland activity, and upregulate antioxidant defences including superoxide dismutase and catalase.

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research into the pineal gland peptide complex epithalamin. It is researched for its role in regulating melatonin secretion, antioxidant enzyme activity, and telomere dynamics, with a body of work primarily from Russian research groups.