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LongevityLow Risk

Epithalon

Also known as: Epitalon, Epithalamin, Ala-Glu-Asp-Gly

Half-life:
30–60 minutes

Administration Routes

subcutaneousintravenous
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Mechanism of Action

Epithalon is believed to activate telomerase, the enzyme responsible for maintaining telomere length, with several in vitro and animal studies reporting telomere elongation. It also appears to regulate the expression of p53 and other cell-cycle control genes, modulate the hypothalamic-pituitary axis via pineal gland activity, and upregulate antioxidant defences including superoxide dismutase and catalase.

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed from research into the pineal gland peptide complex epithalamin. It is researched for its role in regulating melatonin secretion, antioxidant enzyme activity, and telomere dynamics, with a body of work primarily from Russian research groups.

Primary Research Areas

  • longevity
  • skin_joint

Risk Profile

Low Risk

Generally considered lower risk in research contexts. Consult a healthcare professional before use.

Providers Offering Epithalon