Home›Research›Compare›Kisspeptin-54 vs Melanotan II
Peptide ComparisonKisspeptin-54 vs Melanotan II
Both are Reproductive & Hormonal peptides.
Kisspeptin-54
KP-54
Half-life: ~29 minutes
12 providers listed
Melanotan II
MT-II
Half-life: ~1-2 hours
92 providers listed
Kisspeptin-54 carries stronger published evidence (RCT, 8 key studies) than Melanotan II (RCT, 2); both are research compounds.
Kisspeptin-54
Evidence
Half-life
~29 minutes
Melanotan II
Evidence
Half-life
~1-2 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Kisspeptin-54 |
| Further along in FDA review | Kisspeptin-54 |
| Less frequent dosing (longer half-life) | Melanotan II |
| More provider options (12 vs 92) | Melanotan II |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Kisspeptin-54
Melanotan II
Kisspeptin-54
Can kisspeptin be a new treatment for sexual dysfunction?
Phase-dependent changes in serum kisspeptin and irisin levels across the menstrual cycle in healthy women
Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire Disorder: A Randomized Clinical T…
Kisspeptin and LH pulsatility in patients with functional hypothalamic amenorrhea
+4 more
Melanotan II
About Kisspeptin-54
Full-length kisspeptin (54 amino acids); binds KISS1R on GnRH neurons with higher receptor occupancy and longer duration than KP-10; induces more sustained GnRH/LH pulses
About Melanotan II
Synthetic melanocortin receptor agonist (MC1R-MC5R); activates MC4R for erectile function/libido; MC1R for melanogenesis; MC3R for appetite suppression
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Kisspeptin-54
No established clinical contraindications
Melanotan II
Class-based (investigational)
Melanotan II
Antihypertensive medications
Research notes that Melanotan II may influence cardiovascular function via melanocortin receptor activation. Combined use with antihypertensive medications may require blood pressure monitoring. Consult your prescriber before combining.
Kisspeptin-54
Not enough vendor pricing yet.
Melanotan II
Where to source these peptides
Kisspeptin-54
12 listed
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Providers offeringMelanotan II
92 listed
Browse directory →
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More Reproductive & Hormonal Comparisons
Browse all peptides →Educational research tools — not medical advice.
Cite this page
Data last updated July 20, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Kisspeptin-54 vs Melanotan II — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/kisspeptin-54/melanotan-ii