Educational use only — not medical advice
Research library
Klotho benefits
From the PeptideBase research library. Educational only — not medical advice.
Studied effects
- neuroprotection
- cardiovascular protection
- anti-aging
- cognitive support
- anti-fibrotic
Mechanism
Acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. As a circulating hormone, inhibits insulin/IGF-1 signaling to extend lifespan, activates Nrf2 antioxidant pathways, and suppresses TGF-β fibrotic signaling.