About Klotho
Acts as a co-receptor for FGF23, regulating phosphate and vitamin D metabolism. As a circulating hormone, inhibits insulin/IGF-1 signaling to extend lifespan, activates Nrf2 antioxidant pathways, and suppresses TGF-β fibrotic signaling.
A fragment of the anti-aging Klotho protein that circulates as a hormone after ectodomain shedding. Naturally declines with age. Low Klotho levels are associated with accelerated aging, cognitive decline, cardiovascular disease, and reduced lifespan in animal models.
Research Areas
Regulatory & Evidence
Risk Profile
Moderate risk profile in research contexts. Review contraindications and administration guidelines before use.
Regulatory Status
- Availability Status
- Research Only
Regulatory status reflects publicly available information and may change. This is not legal or medical advice.
Safety Notes
Moderate risk profile. Review all reported considerations carefully before use.
Reported contraindications & considerations
Consult a qualified healthcare professional before making any health decisions. This information is educational only and does not constitute medical advice.
Where to Find Klotho
Coverage expanding
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Frequently Asked Questions — Klotho
A fragment of the anti-aging Klotho protein that circulates as a hormone after ectodomain shedding. Naturally declines with age.
neuroprotection, cardiovascular protection, anti-aging, cognitive support, anti-fibrotic.