Ac-SDKP vs Angiotensin (1-7)

Inhibits hematopoietic stem cell entry into S-phase. Blocks TGF-β1-mediated fibroblast activation, reducing collagen deposition. Promotes angiogenesis via VEGF upregulation. Regulated in vivo by ACE enzyme.

A naturally occurring tetrapeptide derived from thymosin beta-4 cleavage by prolyl oligopeptidase. Potent anti-fibrotic properties studied in cardiac, pulmonary, and renal fibrosis. Also promotes angiogenesis and wound healing.

Binds Mas receptor (MasR), activating nitric oxide synthase and reducing oxidative stress. Opposes TGF-β and angiotensin II signaling to reduce fibrosis. Enhances insulin sensitivity and provides cardiovascular protection.

A heptapeptide formed from angiotensin II via ACE2 cleavage, or from angiotensin I via neprilysin. Acts as the endogenous counter-regulatory axis to angiotensin II — producing vasodilation, anti-fibrotic, and metabolic benefits via the Mas receptor.