Home›Research›Compare›Alpha-MSH vs Melanotan II
Peptide ComparisonAlpha-MSH vs Melanotan II
Both are Reproductive & Hormonal peptides.
Alpha-MSH
Alpha-Melanocyte Stimulating Hormone
Half-life: ~3-5 minutes (plasma)
No providers listed yet
Melanotan II
MT-II
Half-life: ~1-2 hours
92 providers listed
Melanotan II has a longer half-life than Alpha-MSH, so it generally needs less frequent dosing.
Alpha-MSH
Evidence
Half-life
~3-5 minutes (plasma)
Melanotan II
Evidence
Half-life
~1-2 hours
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Alpha-MSH |
| Less frequent dosing (longer half-life) | Melanotan II |
| More provider options (0 vs 92) | Melanotan II |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Alpha-MSH
Melanotan II
Alpha-MSH
Depigmenting Effects of Vitex rotundifolia Cone Essential Oil in Melanocytes and Its Chemical Composition.
Antrodia cinnamomea extract exhibits anti-melanogenic and anti-photoaging effects: potential for cosmetic and…
Preclinical assessment of (177)Lu-DOTA-Pip-Nle-CycMSH(hex): In vivo evaluation and human dosimetry estimation.
Hypothalamic orexigenic and anorexigenic neuropeptides in the rotenone model of Parkinson's disease.
+8 more
Melanotan II
About Alpha-MSH
Melanocortin peptide; activates MC1R (pigmentation/anti-inflammatory), MC3R (energy balance), MC4R (appetite); suppresses NF-κB and pro-inflammatory cytokines
About Melanotan II
Synthetic melanocortin receptor agonist (MC1R-MC5R); activates MC4R for erectile function/libido; MC1R for melanogenesis; MC3R for appetite suppression
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Alpha-MSH
No established clinical contraindications
Melanotan II
Class-based (investigational)
Melanotan II
Antihypertensive medications
Research notes that Melanotan II may influence cardiovascular function via melanocortin receptor activation. Combined use with antihypertensive medications may require blood pressure monitoring. Consult your prescriber before combining.
Alpha-MSH
Not enough vendor pricing yet.
Melanotan II
Where to source these peptides
Alpha-MSH
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Providers offeringMelanotan II
92 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More Reproductive & Hormonal Comparisons
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Cite this page
Data last updated July 20, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Alpha-MSH vs Melanotan II — Per-mg Price Comparison. Retrieved July 22, 2026, from https://peptidebase.io/peptides/compare/alpha-msh/melanotan-ii