FGF-1 vs KGF-1

Binds all four FGFR subtypes (broadest binding of FGF family). Activates MAPK and PI3K downstream pathways. Promotes fibroblast proliferation, angiogenesis, and hair follicle cycling into anagen phase.

A member of the fibroblast growth factor family that promotes cell growth, tissue repair, and angiogenesis across multiple cell types. Studied for wound healing, hair follicle stimulation, and skin rejuvenation.

Binds FGFR2b (the KGF receptor), which is exclusively expressed on epithelial cells — providing tissue-specific action without mesenchymal effects. Activates RAS/MAPK and PI3K/Akt to promote keratinocyte proliferation and migration. Extends the anagen phase of the hair growth cycle.

A member of the fibroblast growth factor family that specifically and exclusively targets epithelial cells via FGFR2b. A potent stimulator of keratinocyte proliferation with applications in wound healing, hair follicle growth, and mucosal repair.