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Peptide Comparison

FGF-1 vs Leuphasyl

Both are Skin & Cosmetic peptides.

FGF-1

Fibroblast Growth Factor 1

Skin & JointNot EvaluatedResearch Only

No providers listed yet

Full FGF-1 profile →
vs

Leuphasyl

Acetyl Tetrapeptide-2

Skin & JointNot EvaluatedResearch Only

Half-life: N/A (topical)

No providers listed yet

Full Leuphasyl profile →
Bottom line

FGF-1 carries stronger published evidence (RCT, 1 key studies) than Leuphasyl (In vitro, 1); both are research compounds.

Quick Verdict

FGF-1

Leuphasyl

Which One Should You Choose?
Your goalBetter option
Stronger clinical evidenceFGF-1

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison
FGF-1
Leuphasyl
Mechanism Family
Skin & Cosmetic
Skin & Cosmetic
Half-life
—
N/A (topical)
FDA Status
not evaluated
not evaluated
Admin Routes
topical, subcutaneous
topical
Availability
Research Only
Research Only
Providers
None listed
None listed
Avail. Notes
—
Cosmetic peptide (pentapeptide-18), enkephalin analog. Sold as cosmetic anti-wrinkle ingredient. Not regulated as a drug by FDA. No NDA or IND. Cosmetic use only.
Research Evidence

FGF-1

RCT · 1 key study · dated evidence base — most recent 2008

Leuphasyl

In vitro · 1 key study · most recent 2026
Research Citations

About FGF-1

Binds all four FGFR subtypes (broadest binding of FGF family). Activates MAPK and PI3K downstream pathways. Promotes fibroblast proliferation, angiogenesis, and hair follicle cycling into anagen phase.

Research Areas
wound healinghair growth supportskin repairangiogenesisfibroblast activation

About Leuphasyl

Tetrapeptide that mimics enkephalin to modulate facial muscle contraction; competes with enkephalin for opioid receptor sites in neuromuscular junctions; reduces repetitive muscle micro-contractions

Research Areas
expression line reductionfacial muscle relaxationenkephalin pathway modulation
Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

FGF-1

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Leuphasyl

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Find Providers

Where to source these peptides

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

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Educational research tools — not medical advice.

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