What is the difference between FGF-1 and Palmitoyl Tripeptide-1?

FGF-1: Binds all four FGFR subtypes (broadest binding of FGF family). Activates MAPK and PI3K downstream pathways. Promotes fibroblast proliferation, angiogenesis, and hair follicle cycling into anagen phase. Palmitoyl Tripeptide-1: Palmitoylated GHK fragment; stimulates collagen I, III, and IV synthesis via TGF-β pathway; increases fibronectin and hyaluronic acid production

Is FGF-1 FDA approved?

FGF-1 is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

Is Palmitoyl Tripeptide-1 FDA approved?

Palmitoyl Tripeptide-1 is not evaluated or approved by the FDA. It is discussed for research and educational purposes only, not as medical guidance.

How is FGF-1 administered in research settings?

In research settings, FGF-1 is typically administered via the topical or subcutaneous routes. PeptideBase does not provide dosing or administration instructions.

How is Palmitoyl Tripeptide-1 administered in research settings?

In research settings, Palmitoyl Tripeptide-1 is typically administered via the topical route. PeptideBase does not provide dosing or administration instructions.

Home›Research›Compare›FGF-1 vs Palmitoyl Tripeptide-1

Peptide Comparison

FGF-1 vs Palmitoyl Tripeptide-1

Both are Skin & Cosmetic peptides.

FGF-1

Fibroblast Growth Factor 1

Skin & JointNot EvaluatedResearch Only

No providers listed yet

Full FGF-1 profile →

Palmitoyl Tripeptide-1

Pal-GHK

Skin & JointNot EvaluatedResearch Only

Half-life: N/A (topical)

4 providers listed

Full Palmitoyl Tripeptide-1 profile →

Bottom line

FGF-1 carries stronger published evidence (RCT, 1 key studies) than Palmitoyl Tripeptide-1 (Review, 2); both are research compounds.

Quick Verdict

FGF-1

Palmitoyl Tripeptide-1

Which One Should You Choose?

Your goal	Better option
Stronger clinical evidence	FGF-1
More provider options (0 vs 4)	Palmitoyl Tripeptide-1

Research summary only — not medical advice. Consult a qualified provider before making any decisions.

Side-by-Side Comparison

FGF-1

Palmitoyl Tripeptide-1

Mechanism Family

Skin & Cosmetic

Half-life

—

N/A (topical)

FDA Status

not evaluated

Admin Routes

topical, subcutaneous

topical

Availability

Research Only

Providers

None listed

4 listed

Avail. Notes

—

Cosmetic peptide (Pal-GHK, palmitoyl tripeptide-1). Palmitate conjugate of GHK tripeptide. Not regulated as a drug by FDA. No NDA or IND. Cosmetic anti-aging ingredient only.

Research Evidence

FGF-1

RCT · 1 key study · dated evidence base — most recent 2008

Palmitoyl Tripeptide-1

Review · 2 key studies · dated evidence base — most recent 2015

Research Citations

FGF-1

RCT2008 · Molecular Therapy

Therapeutic angiogenesis with intramuscular NV1FGF improves amputation-free survival in patients with critica…

Palmitoyl Tripeptide-1

In vitro2012 · Journal of Peptide Science

Stem cell recovering effect of copper-free GHK in skin

Review2015 · BioMed Research International

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

About FGF-1

Binds all four FGFR subtypes (broadest binding of FGF family). Activates MAPK and PI3K downstream pathways. Promotes fibroblast proliferation, angiogenesis, and hair follicle cycling into anagen phase.

Research Areas

wound healinghair growth supportskin repairangiogenesisfibroblast activation

About Palmitoyl Tripeptide-1

Palmitoylated GHK fragment; stimulates collagen I, III, and IV synthesis via TGF-β pathway; increases fibronectin and hyaluronic acid production

Research Areas

collagen synthesisskin firmnessanti-agingwound healing

Safety Profile

Information below reflects published research data only — not medical advice. Consult a qualified provider before use.

FGF-1

Absolute Contraindications

Under clinical review

Being verified by our medical team before we display contraindications for this peptide.

Palmitoyl Tripeptide-1

No established clinical contraindications. This is an investigational compound with limited human data and has not been evaluated by the FDA for safety in this context. Consult a qualified clinician.

Find Providers

Where to source these peptides

Providers offering

FGF-1

Browse directory →

Providers offering

Palmitoyl Tripeptide-1

4 listed

Browse directory →

PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.

More Skin & Cosmetic Comparisons

Browse all peptides →

Educational research tools — not medical advice.