Home›Research›Compare›Ghrelin vs IGF-2
Peptide ComparisonGhrelin vs IGF-2
Both are GH / IGF Axis peptides.
Ghrelin
acyl ghrelin
Half-life: ~24 min (initial), ~146 min (terminal)
3 providers listed
IGF-2
Insulin-like Growth Factor 2
Half-life: ~10-20 minutes
No providers listed yet
Ghrelin carries stronger published evidence (RCT, 9 key studies) than IGF-2 (Cohort study, 8); both are research compounds.
Ghrelin
Evidence
Half-life
~24 min (initial), ~146 min (terminal)
IGF-2
Evidence
Half-life
~10-20 minutes
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Ghrelin |
| Less frequent dosing (longer half-life) | Ghrelin |
| More provider options (3 vs 0) | Ghrelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Ghrelin
IGF-2
Ghrelin
Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeo…
A Secondary, Subgroup Analysis of Alcohol Cue-Exposure Craving in Response to Pharmacological Inhibition of t…
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
Metabolomic and proteomic analysis of ghrelin administration in mice infected with Echinococcus granulosus.
+5 more
IGF-2
An engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling.
Paraneoplastic hypoglycemia as the initial presentation of a pancreatic neuroendocrine tumor.
Proteomics and ex vivo plaque culture identify the insulin-like growth factor axis as a potential regulator o…
The IGF signaling axis in thyroid cancer: biological complexity and therapeutic challenges.
+4 more
About Ghrelin
Must be acylated at Ser3 (by GOAT enzyme) for GHSR-1a binding. Receptor activation in the pituitary stimulates GH release; hypothalamic action via NPY/AgRP neurons increases appetite and reduces energy expenditure.
About IGF-2
Binds IGF-1R and insulin receptor variant A; promotes anabolic signaling in muscle and fat; activates PI3K/Akt/mTOR pathway; different receptor binding profile than IGF-1
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Ghrelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
IGF-2
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Where to source these peptides
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.