Home›Research›Compare›Ghrelin vs IGF-2
Peptide ComparisonGhrelin vs IGF-2
Both are GH / IGF Axis peptides.
Ghrelin
acyl ghrelin
Half-life: ~24 min (initial), ~146 min (terminal)
3 providers listed
IGF-2
Insulin-like Growth Factor 2
Half-life: ~10-20 minutes
No providers listed yet
Ghrelin carries stronger published evidence (RCT, 5 key studies) than IGF-2 (Case series, 6); both are research compounds.
Ghrelin
Half-life
~24 min (initial), ~146 min (terminal)
IGF-2
Half-life
~10-20 minutes
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Ghrelin |
| Less frequent dosing (longer half-life) | Ghrelin |
| More provider options (3 vs 0) | Ghrelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Ghrelin
IGF-2
Ghrelin
A Secondary, Subgroup Analysis of Alcohol Cue-Exposure Craving in Response to Pharmacological Inhibition of t…
Pilot clinical trial of macimorelin to assess safety and efficacy in patients with cancer cachexia
Safety, tolerability, pharmacokinetics, and pharmacodynamics of macimorelin in healthy adults: Results of a s…
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
+1 more
IGF-2
IGF-2-mediated hypoglycemia in a patient with a phyllodes tumor of the breast: a rare presentation of non-isl…
Proteomics and ex vivo plaque culture identify the insulin-like growth factor axis as a potential regulator o…
TGF-β inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II
Autocrine growth factor signaling by insulin-like growth factor-II mediates MyoD-stimulated myocyte maturation
+2 more
About Ghrelin
Must be acylated at Ser3 (by GOAT enzyme) for GHSR-1a binding. Receptor activation in the pituitary stimulates GH release; hypothalamic action via NPY/AgRP neurons increases appetite and reduces energy expenditure.
About IGF-2
Binds IGF-1R and insulin receptor variant A; promotes anabolic signaling in muscle and fat; activates PI3K/Akt/mTOR pathway; different receptor binding profile than IGF-1
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Ghrelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
IGF-2
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Where to source these peptides
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.