Ghrelin vs GHRP-2

Must be acylated at Ser3 (by GOAT enzyme) for GHSR-1a binding. Receptor activation in the pituitary stimulates GH release; hypothalamic action via NPY/AgRP neurons increases appetite and reduces energy expenditure.

An endogenous 28-amino acid peptide hormone produced primarily by gastric oxyntic cells. Functions as both the primary hunger signal and a potent GH secretagogue. The natural ligand for the growth hormone secretagogue receptor (GHSR-1a).

Synthetic hexapeptide that stimulates pulsatile growth hormone release from the anterior pituitary by acting on the ghrelin receptor (GHSR-1a). Commonly stacked with GHRH analogs such as CJC-1295 or Sermorelin to amplify GH output synergistically.

GHRP-2 is a synthetic growth hormone secretagogue that triggers natural GH release from the pituitary gland. It is commonly used alongside GHRH analogs to support muscle growth, fat loss, and recovery. For educational purposes only — consult a qualified healthcare provider.