Home›Research›Compare›Ghrelin vs Sermorelin
Peptide ComparisonGhrelin vs Sermorelin
Both are GH / IGF Axis peptides.
Ghrelin
acyl ghrelin
Half-life: ~24 min (initial), ~146 min (terminal)
3 providers listed
Sermorelin
GHRH 1-29
Half-life: 10–20 minutes
445 providers listed
Ghrelin carries stronger published evidence (RCT, 9 key studies) than Sermorelin (RCT, 3); both are research compounds.
Ghrelin
Evidence
Half-life
~24 min (initial), ~146 min (terminal)
Sermorelin
Evidence
Half-life
10–20 minutes
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Ghrelin |
| Less frequent dosing (longer half-life) | Ghrelin |
| More provider options (3 vs 445) | Sermorelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
Ghrelin
Sermorelin
Ghrelin
Associations of PYY, GLP-1 and LEAP2 with changes in feeding-related cognition, body weight and glucose homeo…
A Secondary, Subgroup Analysis of Alcohol Cue-Exposure Craving in Response to Pharmacological Inhibition of t…
Constant intravenous ghrelin infusion in healthy young men: clinical pharmacokinetics and metabolic effects
Metabolomic and proteomic analysis of ghrelin administration in mice infected with Echinococcus granulosus.
+5 more
Sermorelin
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…
The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients…
The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostat…
About Ghrelin
Must be acylated at Ser3 (by GOAT enzyme) for GHSR-1a binding. Receptor activation in the pituitary stimulates GH release; hypothalamic action via NPY/AgRP neurons increases appetite and reduces energy expenditure.
About Sermorelin
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
Ghrelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin clinical protocols measure IGF-1 as the primary marker of GH axis response. Fasting glucose and insulin are standard baseline assessments given GH's effect on insulin sensitivity.
Sermorelin
Ipamorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.
Ghrelin
Not enough vendor pricing yet.
Sermorelin
Where to source these peptides
Ghrelin
3 listed
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Providers offeringSermorelin
445 listed
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PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.
Cite this page
Data last updated July 27, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). Ghrelin vs Sermorelin — Per-mg Price Comparison. Retrieved July 29, 2026, from https://peptidebase.io/peptides/compare/ghrelin/sermorelin