Home›Research›Compare›IGF-1 vs Sermorelin
Peptide ComparisonIGF-1 vs Sermorelin
Both are GH / IGF Axis peptides.
IGF-1
Insulin-like Growth Factor 1
21 providers listed
Sermorelin
GHRH 1-29
Half-life: 10–20 minutes
449 providers listed
IGF-1 is FDA-approved, while Sermorelin is not evaluated — the clearest structural difference between them.
IGF-1
Half-life
—
Sermorelin
Half-life
10–20 minutes
| Your goal | Better option |
|---|---|
| Stronger clinical evidence | Sermorelin |
| Further along in FDA review | IGF-1 |
| Lower typical price per mg | Sermorelin |
| More provider options (21 vs 449) | Sermorelin |
Research summary only — not medical advice. Consult a qualified provider before making any decisions.
IGF-1
Sermorelin
Sermorelin
The GH response to low-dose bolus growth hormone-releasing hormone (GHRH(1-29)NH2) is attenuated in patients…
The relative roles of continuous growth hormone-releasing hormone (GHRH(1-29)NH2) and intermittent somatostat…
A new era of doping? Use of peptide and peptide-analog drugs in recreational and professional sport and bodyb…
About IGF-1
Binds IGF-1R with high affinity, activating PI3K/Akt and MAPK pathways promoting protein synthesis, satellite cell activation, and glucose uptake. Much shorter half-life (~15 min) than the LR3 analog (~20-30 hr) due to binding protein interactions.
About Sermorelin
Sermorelin is a synthetic analogue of the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH). It binds to GHRH receptors on pituitary somatotrophs, stimulating pulsatile GH secretion in a physiological pattern that preserves the natural hypothalamic-pituitary feedback axis — contrasting with direct GH administration. Downstream IGF-1 elevation mediates many of its body composition, tissue-repair, and sleep quality effects.
Information below reflects published research data only — not medical advice. Consult a qualified provider before use.
IGF-1
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Under clinical review
Being verified by our medical team before we display monitoring guidance for this peptide.
Sermorelin
Under clinical review
Being verified by our medical team before we display contraindications for this peptide.
Sermorelin clinical protocols measure IGF-1 as the primary marker of GH axis response. Fasting glucose and insulin are standard baseline assessments given GH's effect on insulin sensitivity.
Sermorelin
Ipamorelin
Research suggests Sermorelin and Ipamorelin may produce complementary growth hormone release effects when combined. Sermorelin acts as a GHRH analogue via pituitary receptors, while Ipamorelin acts via ghrelin receptors — dual-pathway stimulation studied in GH optimization research.
IGF-1
Sermorelin
Where to source these peptides
IGF-1
21 listed
Browse directory →
Providers offeringSermorelin
449 listed
Browse directory →
PeptideBase lists providers for educational research purposes only. Always consult a qualified healthcare professional before obtaining or using any peptide.
More GH / IGF Axis Comparisons
Browse all peptides →Educational research tools — not medical advice.
Cite this page
Data last updated August 26, 2026
Free to reference and republish with attribution to PeptideBase. Choose a format:
PeptideBase. (2026). IGF-1 vs Sermorelin — Per-mg Price Comparison. Retrieved September 12, 2026, from https://peptidebase.io/peptides/compare/igf-1/sermorelin