Home / Combinations / MK-677 + Epithalon
CombinationSleepAnti-AgingAnecdotal evidence
MK-677 + Epithalon
Sleep Architecture & Anti-Aging
MK-677 (ibutamoren), an orally active ghrelin mimetic, is commonly researched for improving REM and slow-wave sleep alongside GH pulse enhancement. Combined with Epithalon's research into pineal peptide bioregulation and telomere dynamics, this stack is explored for both sleep quality and longevity-related outcomes.
Stack components
MK-677Compound 01
EpithalonCompound 02
2
Compounds
2
Sources on file
15
Providers carry all
Mechanism
What each compound is researched for on its own. Nothing here describes an interaction between them.
Compound 01
MK-677
Oral ghrelin mimetic that elevates GH and IGF-1 and has been specifically researched for increasing REM sleep duration and slow-wave sleep depth in older adults.
Compound 02
Epithalon
Tetrapeptide bioregulator of the pineal gland researched for telomerase activation, melatonin normalization, and extension of healthy lifespan in multiple experimental models.
Composition
2 compounds · 2 research areas
Stated as recorded. This page describes each compound separately and makes no claim that they act together.
Safety notes
MK-677 may transiently increase appetite and blood glucose; researchers with insulin-sensitivity concerns note this in study exclusions. Epithalon has a well-documented safety profile across decades of Russian clinical research. No formal combination study data exists.
Author-written. Not derived from any compound field, and not covered by the profile-integrity audit that gates the peptide pages.
Research references2 sources
Strong
Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults
Ann Intern Med 2008
PeptideBase noteMK-677 component study — no combination study exists
Moderate
Effect of Epithalon on the lifespan increase in Drosophila melanogaster
Mech Ageing Dev 2000
PeptideBase noteEpithalon component study — no combination study exists
no identifier on file
Related combinations3 share an area
Educational use only
PeptideBase documents what compounds are researched together and what evidence exists for each one separately. It does not provide medical advice, diagnosis, treatment, prescribing guidance or dosing instructions. Last reviewed 23 Apr 2026.
PeptideBase documents what compounds are researched together and what evidence exists for each one separately. It does not provide medical advice, diagnosis, treatment, prescribing guidance or dosing instructions. Last reviewed 23 Apr 2026.