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PerformanceMedium Risk

MK-677

Also known as: Ibutamoren, MK-0677, Nutrobal

Half-life:
24 hours

Administration Routes

oral
PeptideBase provides educational research tools and provider discovery. It does not provide medical advice, diagnosis, treatment, prescribing guidance, or dosing instructions. Consult a qualified healthcare professional before making health decisions.

Mechanism of Action

MK-677 mimics the action of ghrelin by binding to and activating the GHSR-1a receptor in the pituitary gland, stimulating pulsatile GH release. Its oral bioavailability distinguishes it from peptide-based GH secretagogues and its prolonged half-life results in sustained IGF-1 elevation. Research protocols have explored its effects on lean body mass, bone mineral density, and sleep architecture.

MK-677 (Ibutamoren) is an orally active, non-peptide ghrelin receptor agonist and growth hormone secretagogue. Unlike injectable GH peptides, it is taken orally and provides sustained elevation of GH and IGF-1 levels throughout the day. It is commonly researched for muscle and body composition outcomes, and is of particular interest for users who prefer oral administration routes.

Primary Research Areas

  • performance
  • fat_loss
  • recovery
  • longevity

Risk Profile

Medium Risk

Moderate risk profile in research contexts. Consult a healthcare professional before use.

Providers Offering MK-677